Signal Transduction Antibodies 2

Anti-LSM14A Antibody (CAB16682)

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SKU:
CAB16682
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-LSM14A Antibody
Antibody SKU:CAB16682
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide of human LSM14A
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse brain, Rat liver
Immunogen:A synthetic peptide of human LSM14A
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:26065
Uniprot:Q8ND56
Cellular Location:Cytoplasm, P-body
Calculated MW:46kDa/50kDa
Observed MW:50kDa
Synonyms:LSM14A, C19orf13, FAM61A, RAP55, RAP55A
Background:Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Mar 2008]
UniProt Protein Function:alphaSNBP(A): Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for non-translating mRNAs. Belongs to the LSM14 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Translation; RNA-binding

Chromosomal Location of Human Ortholog: 19q13.11

Cellular Component: intracellular membrane-bound organelle; stress granule; cytoplasm

Molecular Function:single-stranded RNA binding; double-stranded DNA binding; double-stranded RNA binding

Biological Process: regulation of translation; multicellular organismal development; cytoplasmic mRNA processing body assembly

NCBI Summary:Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Mar 2008]
UniProt Code:Q8ND56
NCBI GenInfo Identifier:71648673
NCBI Gene ID:26065
NCBI Accession:Q8ND56.3
UniProt Related Accession:Q8ND56
Molecular Weight:
NCBI Full Name:Protein LSM14 homolog A
NCBI Synonym Full Names:LSM14A mRNA processing body assembly factor
NCBI Official Symbol:LSM14A  
NCBI Official Synonym Symbols:RAP55; FAM61A; RAP55A; C19orf13  
NCBI Protein Information:protein LSM14 homolog A
UniProt Protein Name:Protein LSM14 homolog A
UniProt Synonym Protein Names:Protein FAM61A; Protein SCD6 homolog; Putative alpha-synuclein-binding protein; AlphaSNBP; RNA-associated protein 55A; hRAP55; hRAP55A
UniProt Gene Name:LSM14A  
UniProt Entry Name:LS14A_HUMAN
Anti-LSM14A Antibody (CAB16682)Western blot analysis of extracts of various cell lines, using LSM14A Rabbit pAb (CAB16682) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.
Anti-LSM14A Antibody (CAB16682)Immunofluorescence analysis of L929 cells using LSM14A antibody (CAB16682) at dilution of 1:100. Blue: DAPI for nuclear staining.
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