Signal Transduction Antibodies 2
Anti-LSM14A Antibody (CAB16682)
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- SKU:
- CAB16682
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-LSM14A Antibody |
| Antibody SKU: | CAB16682 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide of human LSM14A |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse brain, Rat liver |
| Immunogen: | A synthetic peptide of human LSM14A |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 26065 |
| Uniprot: | Q8ND56 |
| Cellular Location: | Cytoplasm, P-body |
| Calculated MW: | 46kDa/50kDa |
| Observed MW: | 50kDa |
| Synonyms: | LSM14A, C19orf13, FAM61A, RAP55, RAP55A |
| Background: | Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Mar 2008] |
| UniProt Protein Function: | alphaSNBP(A): Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for non-translating mRNAs. Belongs to the LSM14 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Translation; RNA-binding Chromosomal Location of Human Ortholog: 19q13.11 Cellular Component: intracellular membrane-bound organelle; stress granule; cytoplasm Molecular Function:single-stranded RNA binding; double-stranded DNA binding; double-stranded RNA binding Biological Process: regulation of translation; multicellular organismal development; cytoplasmic mRNA processing body assembly |
| NCBI Summary: | Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q8ND56 |
| NCBI GenInfo Identifier: | 71648673 |
| NCBI Gene ID: | 26065 |
| NCBI Accession: | Q8ND56.3 |
| UniProt Related Accession: | Q8ND56 |
| Molecular Weight: | |
| NCBI Full Name: | Protein LSM14 homolog A |
| NCBI Synonym Full Names: | LSM14A mRNA processing body assembly factor |
| NCBI Official Symbol: | LSM14A |
| NCBI Official Synonym Symbols: | RAP55; FAM61A; RAP55A; C19orf13 |
| NCBI Protein Information: | protein LSM14 homolog A |
| UniProt Protein Name: | Protein LSM14 homolog A |
| UniProt Synonym Protein Names: | Protein FAM61A; Protein SCD6 homolog; Putative alpha-synuclein-binding protein; AlphaSNBP; RNA-associated protein 55A; hRAP55; hRAP55A |
| UniProt Gene Name: | LSM14A |
| UniProt Entry Name: | LS14A_HUMAN |
 | Western blot analysis of extracts of various cell lines, using LSM14A Rabbit pAb (CAB16682) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
 | Immunofluorescence analysis of L929 cells using LSM14A antibody (CAB16682) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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