Epigenetics & Nuclear Signaling Antibodies 1
Anti-LSM1 Antibody (CAB12732)
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- SKU:
- CAB12732
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-LSM1 Antibody |
| Antibody SKU: | CAB12732 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-133 of human LSM1 (NP_055277.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:1000 - 1:3000 IHC 1:50 - 1:200 |
| Reactivity: | Human |
| Positive Samples: | Raji, 293T, HeLa |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-133 of human LSM1 (NP_055277.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MNYM PGTA SLIE DIDK KHLV LLRD GRTL IGFL RSID QFAN LVLH QTVE RIHV GKKY GDIP RGIF VVRG ENVV LLGE IDLE KESD TPLQ QVSI EEIL EEQR VEQQ TKLE AEKL KVQA LKDR GLSI PRAD TLDE Y |
| Gene ID: | 27257 |
| Uniprot: | O15116 |
| Cellular Location: | Nucleus |
| Calculated MW: | 15kDa |
| Observed MW: | 17kDa |
| Synonyms: | LSM1, CASM, YJL124C |
| Background: | This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Increased expression of this gene may play a role in cellular transformation and the progression of several malignancies including lung cancer, mesothelioma and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. |
| UniProt Protein Function: | LSM1: Plays a role in replication-dependent histone mRNA degradation. Binds specifically to the 3'-terminal U-tract of U6 snRNA. Belongs to the snRNP Sm proteins family. |
| UniProt Protein Details: | Protein type:RNA-binding Chromosomal Location of Human Ortholog: 8p11.23 Cellular Component: cytoplasm; cytosol; nucleus Molecular Function:protein binding; RNA binding; RNA cap binding Biological Process: deadenylation-dependent decapping; RNA splicing; RNA splicing, via transesterification reactions |
| NCBI Summary: | This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Increased expression of this gene may play a role in cellular transformation and the progression of several malignancies including lung cancer, mesothelioma and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Nov 2011] |
| UniProt Code: | O15116 |
| NCBI GenInfo Identifier: | 20177943 |
| NCBI Gene ID: | 27257 |
| NCBI Accession: | O15116.1 |
| UniProt Secondary Accession: | O15116,B2R5E6, |
| UniProt Related Accession: | O15116 |
| Molecular Weight: | 15kDa |
| NCBI Full Name: | U6 snRNA-associated Sm-like protein LSm1 |
| NCBI Synonym Full Names: | LSM1 homolog, mRNA degradation associated |
| NCBI Official Symbol: | LSM1 |
| NCBI Official Synonym Symbols: | CASM; YJL124C |
| NCBI Protein Information: | U6 snRNA-associated Sm-like protein LSm1 |
| UniProt Protein Name: | U6 snRNA-associated Sm-like protein LSm1 |
| UniProt Synonym Protein Names: | Cancer-associated Sm-like; Small nuclear ribonuclear CaSm |
| Protein Family: | Sm-like protein |
| UniProt Gene Name: | LSM1 |
 | Western blot analysis of extracts of various cell lines, using LSM1 antibody (CAB12732) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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