| UniProt Protein Function: | AOF1: Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri- methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys- 36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4. Belongs to the flavin monoamine oxidase family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Oxidoreductase; EC 1.-.-.-Chromosomal Location of Human Ortholog: 6p22.3Cellular Component: nucleoplasm; nucleusMolecular Function: histone demethylase activityBiological Process: genetic imprinting |
| UniProt Protein Details: | |
| NCBI Summary: | Flavin-dependent histone demethylases, such as KDM1B, regulate histone lysine methylation, an epigenetic mark that regulates gene expression and chromatin function (Karytinos et al., 2009 [PubMed 19407342]).[supplied by OMIM, Oct 2009] |
| UniProt Code: | Q8NB78 |
| NCBI GenInfo Identifier: | 317373434 |
| NCBI Gene ID: | 221656 |
| NCBI Accession: | Q8NB78.3 |
| UniProt Secondary Accession: | Q8NB78,Q5TGV3, Q6AI15, Q6ZUU4, Q8N258, Q96EL7, A2A2C5 A2A2C6 |
| UniProt Related Accession: | Q8NB78 |
| Molecular Weight: | 19,428 Da |
| NCBI Full Name: | Lysine-specific histone demethylase 1B |
| NCBI Synonym Full Names: | lysine demethylase 1B |
| NCBI Official Symbol: | KDM1B |
| NCBI Official Synonym Symbols: | AOF1; LSD2; C6orf193; bA204B7.3; dJ298J15.2 |
| NCBI Protein Information: | lysine-specific histone demethylase 1B |
| UniProt Protein Name: | Lysine-specific histone demethylase 1B |
| UniProt Synonym Protein Names: | Flavin-containing amine oxidase domain-containing protein 1; Lysine-specific histone demethylase 2 |
| Protein Family: | Lysine-specific histone demethylase |
| UniProt Gene Name: | KDM1B |
| UniProt Entry Name: | KDM1B_HUMAN |
