Anti-LSD2/KDM1B/AOF1 Antibody (CAB19820)
- SKU:
- CAB19820
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- AOF1
- Synonyms:
- C6orf193
- Synonyms:
- LSD2
- Synonyms:
- bA204B7.3
- Synonyms:
- dJ298J15.2
Description
| Product Name: | LSD2/KDM1B/AOF1 Rabbit mAb |
| Product Code: | CAB19820 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | AOF1, C6orf193, LSD2, bA204B7.3, dJ298J15.2 |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human LSD2/KDM1B/AOF1 |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, HCT116, HepG2 |
| Immunogen: | A synthesized peptide derived from human LSD2/KDM1B/AOF1 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 221656 |
| Uniprot: | Q8NB78 |
| Calculated MW: | 92kDa |
| Observed MW: | 92KDa |
| UniProt Protein Function: | AOF1: Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri- methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys- 36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4. Belongs to the flavin monoamine oxidase family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Oxidoreductase; EC 1.-.-.-Chromosomal Location of Human Ortholog: 6p22.3Cellular Component: nucleoplasm; nucleusMolecular Function: histone demethylase activityBiological Process: genetic imprinting |
| UniProt Protein Details: | |
| NCBI Summary: | Flavin-dependent histone demethylases, such as KDM1B, regulate histone lysine methylation, an epigenetic mark that regulates gene expression and chromatin function (Karytinos et al., 2009 [PubMed 19407342]).[supplied by OMIM, Oct 2009] |
| UniProt Code: | Q8NB78 |
| NCBI GenInfo Identifier: | 317373434 |
| NCBI Gene ID: | 221656 |
| NCBI Accession: | Q8NB78.3 |
| UniProt Secondary Accession: | Q8NB78,Q5TGV3, Q6AI15, Q6ZUU4, Q8N258, Q96EL7, A2A2C5 A2A2C6 |
| UniProt Related Accession: | Q8NB78 |
| Molecular Weight: | 19,428 Da |
| NCBI Full Name: | Lysine-specific histone demethylase 1B |
| NCBI Synonym Full Names: | lysine demethylase 1B |
| NCBI Official Symbol: | KDM1B |
| NCBI Official Synonym Symbols: | AOF1; LSD2; C6orf193; bA204B7.3; dJ298J15.2 |
| NCBI Protein Information: | lysine-specific histone demethylase 1B |
| UniProt Protein Name: | Lysine-specific histone demethylase 1B |
| UniProt Synonym Protein Names: | Flavin-containing amine oxidase domain-containing protein 1; Lysine-specific histone demethylase 2 |
| Protein Family: | Lysine-specific histone demethylase |
| UniProt Gene Name: | KDM1B |
| UniProt Entry Name: | KDM1B_HUMAN |
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