Cell Biology Antibodies 4

Anti-LSAMP Antibody (CAB14248)

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SKU:
CAB14248
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-LSAMP Antibody
Antibody SKU:CAB14248
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-338 of human LSAMP (NP_002329.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:U-87MG, HT-29, Jurkat, HepG2, Mouse small intestine, Rat small intestine
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-338 of human LSAMP (NP_002329.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MVRR VQPD RKQL PLVL LRLL CLLP TGLP VRSV DFNR GTDN ITVR QGDT AILR CVVE DKNS KVAW LNRS GIIF AGHD KWSL DPRV ELEK RHSL EYSL RIQK VDVY DEGS YTCS VQTQ HEPK TSQV YLIV QVPP KISN ISSD VTVN EGSN VTLV CMAN GRPE PVIT WRHL TPTG REFE GEEE YLEI LGIT REQS GKYE CKAA NEVS SADV KQVK VTVN YPPT ITES KSNE ATTG RQAS LKCE ASAV PAPD FEWY RDDT RINS ANGL EIKS TEGQ SSLT VTNV TEEH YGNY TCVA ANKL GVTN ASLV LFRP GSVR GING SISL AVPL WLLA ASLL CLLS KC
Gene ID:4045
Uniprot:Q13449
Cellular Location:Cell membrane, GPI-anchor, Lipid-anchor
Calculated MW:37kDa
Observed MW:34kDa/37kDa
Synonyms:LSAMP, IGLON3, LAMP
Background:This gene encodes a member of the immunoglobulin LAMP, OBCAM and neurotrimin (IgLON) family of proteins. The encoded preproprotein is proteolytically processed to generate a neuronal surface glycoprotein. This protein may act as a selective homophilic adhesion molecule during axon guidance and neuronal growth in the developing limbic system. The encoded protein may also function as a tumor suppressor and may play a role in neuropsychiatric disorders. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed.
UniProt Protein Function:APCS: Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin. SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits. Belongs to the pentaxin family.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted; Chaperone

Chromosomal Location of Human Ortholog: 1q21-q23

Cellular Component: extracellular matrix; extracellular space; protein complex; extracellular region; nucleus

Molecular Function:complement component C1q binding; unfolded protein binding; virion binding; calcium ion binding; carbohydrate binding

Biological Process: protein folding; negative regulation of virion penetration into host cell; acute-phase response; negative regulation of acute inflammatory response; innate immune response; chaperone-mediated protein complex assembly; negative regulation of monocyte differentiation; negative regulation of viral reproduction

NCBI Summary:The protein encoded by this gene is a glycoprotein, belonging to the pentraxin family of proteins, which has a characteristic pentameric organization. These family members have considerable sequence homology which is thought to be the result of gene duplication. The binding of the encoded protein to proteins in the pathological amyloid cross-beta fold suggests its possible role as a chaperone. This protein is also thought to control the degradation of chromatin. It has been demonstrated that this protein binds to apoptotic cells at an early stage, which raises the possibility that it is involved in dealing with apoptotic cells in vivo. [provided by RefSeq, Sep 2008]
UniProt Code:Q13449
NCBI GenInfo Identifier:4502133
NCBI Gene ID:325
NCBI Accession:NP_001630.1
UniProt Secondary Accession:Q13449,Q13449,
UniProt Related Accession:P02743
Molecular Weight:25,387 Da
NCBI Full Name:serum amyloid P-component
NCBI Synonym Full Names:amyloid P component, serum
NCBI Official Symbol:APCS  
NCBI Official Synonym Symbols:SAP; PTX2  
NCBI Protein Information:serum amyloid P-component; pentaxin-related; 9.5S alpha-1-glycoprotein
UniProt Protein Name:Serum amyloid P-component
UniProt Synonym Protein Names:9.5S alpha-1-glycoprotein
UniProt Gene Name:APCS  
UniProt Entry Name:SAMP_HUMAN
Anti-LSAMP Antibody (CAB14248)Western blot analysis of extracts of various cell lines, using LSAMP antibody (CAB14248) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3s.
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