Epigenetics & Nuclear Signaling Antibodies 2
Anti-LRRFIP1 Antibody (CAB15752)
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- SKU:
- CAB15752
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-LRRFIP1 Antibody |
| Antibody SKU: | CAB15752 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 589-808 of human LRRFIP1 (NP_001131024.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | A375, HeLa, LO2 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 589-808 of human LRRFIP1 (NP_001131024.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | KDVK KELT YQNT DLSE IKEE EQVK STDR KSAV EAQN EVTE NPKQ KIAA ESSE NVDC PENP KIKL DGKL DQEG DDVQ TAAE EVLA DGDT LDFE DDTV QSSG PRAG GEEL DEGV AKDN AKID GATQ SSPA EPKS EDAD RCTL PEHE SPSQ DISD ACEA ESTE RCEM SEHP SQTV RKAL DSNS LEND DLSA PGRE PGHF NPES REDT RGGN EKGK SKED CTMS |
| Gene ID: | 9208 |
| Uniprot: | Q32MZ4 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 73kDa/82kDa/86kDa/89kDa |
| Observed MW: | 70kDa |
| Synonyms: | LRRFIP1, FLAP-1, FLAP1, FLIIAP1, GCF-2, GCF2, HUFI-1, TRIP |
| Background: |
| UniProt Protein Function: | LRRFIP1: Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. Belongs to the LRRFIP family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; RNA-binding Chromosomal Location of Human Ortholog: 2q37.3 Cellular Component: cytoskeleton; cytoplasm; plasma membrane; nucleus; cytosol Molecular Function:protein binding; protein homodimerization activity; DNA binding; double-stranded RNA binding Biological Process: regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; positive regulation of interferon type I production; innate immune response; negative regulation of transcription, DNA-dependent |
| UniProt Code: | Q32MZ4 |
| NCBI GenInfo Identifier: | 212276070 |
| NCBI Gene ID: | 9208 |
| NCBI Accession: | NP_004726.2 |
| UniProt Secondary Accession: | Q32MZ4,O75766, O75799, Q32MZ5, Q53T49, Q6PKG2, Q9Y607 E9PGZ2, |
| UniProt Related Accession: | Q32MZ4 |
| Molecular Weight: | 73,060 Da |
| NCBI Full Name: | leucine-rich repeat flightless-interacting protein 1 isoform 4 |
| NCBI Synonym Full Names: | leucine rich repeat (in FLII) interacting protein 1 |
| NCBI Official Symbol: | LRRFIP1 |
| NCBI Official Synonym Symbols: | GCF2; TRIP; FLAP1; GCF-2; FLAP-1; HUFI-1; FLIIAP1 |
| NCBI Protein Information: | leucine-rich repeat flightless-interacting protein 1; GC-binding factor 2; NEDD8-conjugating enzyme; TAR RNA-interacting protein; LRR FLII-interacting protein 1 |
| UniProt Protein Name: | Leucine-rich repeat flightless-interacting protein 1 |
| UniProt Synonym Protein Names: | GC-binding factor 2; TAR RNA-interacting protein |
| UniProt Gene Name: | LRRFIP1 |
| UniProt Entry Name: | LRRF1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using LRRFIP1 antibody (CAB15752) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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