Cell Biology Antibodies 1
Anti-LRRC4 Antibody (CAB10321)
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- SKU:
- CAB10321
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-LRRC4 Antibody |
| Antibody SKU: | CAB10321 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 544-653 of human LRRC4 (NP_071426.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:1000 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-87MG, U-251MG, K-562, Mouse brain, Mouse liver, Rat brain, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 544-653 of human LRRC4 (NP_071426.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LIVF YKLR KRHQ QRST VTAA RTVE IIQV DEDI PAAT SAAA TAAP SGVS GEGA VVLP TIHD HINY NTYK PAHG AHWT ENSL GNSL HPTV TTIS EPYI IQTH TKDK VQET QI |
| Gene ID: | 64101 |
| Uniprot: | Q9HBW1 |
| Cellular Location: | Cell junction, Membrane, Single-pass type I membrane protein, postsynaptic cell membrane, synapse |
| Calculated MW: | 72kDa |
| Observed MW: | 73kDa |
| Synonyms: | LRRC4, NAG14, NGL-2 |
| Background: | This gene is significantly downregulated in primary brain tumors. The exact function of the protein encoded by this gene is unknown. |
| UniProt Protein Function: | LRRC4: Synaptic adhesion protein. Regulates the formation of exitatory synapses through the recruitment of pre-and-postsynaptic proteins. Organize the lamina/pathway-specific differentiation of dendrites. Plays a important role for auditory synaptic responses. Involved in the suppression of glioma. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 7q32.1 Cellular Component: cytoplasm Molecular Function:protein binding; protein kinase inhibitor activity Biological Process: cytokine and chemokine mediated signaling pathway; negative regulation of JAK-STAT cascade; negative regulation of protein kinase activity |
| NCBI Summary: | This gene is significantly downregulated in primary brain tumors. The exact function of the protein encoded by this gene is unknown. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9HBW1 |
| NCBI GenInfo Identifier: | 51701696 |
| NCBI Gene ID: | 64101 |
| NCBI Accession: | Q9HBW1.2 |
| UniProt Secondary Accession: | Q9HBW1,Q14DU9, Q6ZMI8, Q96A85, A4D0Y9, |
| UniProt Related Accession: | Q9HBW1 |
| Molecular Weight: | 73kDa |
| NCBI Full Name: | Leucine-rich repeat-containing protein 4 |
| NCBI Synonym Full Names: | leucine rich repeat containing 4 |
| NCBI Official Symbol: | LRRC4 |
| NCBI Official Synonym Symbols: | NAG14; NGL-2 |
| NCBI Protein Information: | leucine-rich repeat-containing protein 4 |
| UniProt Protein Name: | Leucine-rich repeat-containing protein 4 |
| UniProt Synonym Protein Names: | Brain tumor-associated protein BAG; Nasopharyngeal carcinoma-associated gene 14 protein; Netrin-G2 ligand; NGL-2 |
| Protein Family: | Leucine-rich repeat-containing protein |
| UniProt Gene Name: | LRRC4 |
 | Western blot analysis of extracts of various cell lines, using LRRC4 antibody (CAB10321) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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