Cell Biology Antibodies 1
Anti-LRIG1 Antibody (CAB10297)
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- SKU:
- CAB10297
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-LRIG1 Antibody |
| Antibody SKU: | CAB10297 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 35-220 of human LRIG1 (NP_056356.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:1000 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Raji, Mouse skin, Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 35-220 of human LRIG1 (NP_056356.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | AGPR APCA AACT CAGD SLDC GGRG LAAL PGDL PSWT RSLN LSYN KLSE IDPA GFED LPNL QEVY LNNN ELTA VPSL GAAS SHVV SLFL QHNK IRSV EGSQ LKAY LSLE VLDL SLNN ITEV RNTC FPHG PPIK ELNL AGNR IGTL ELGA FDGL SRSL LTLR LSKN RITQ LPVR AFKL PRLT QLDL NR |
| Gene ID: | 26018 |
| Uniprot: | Q96JA1 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 116kDa/119kDa |
| Observed MW: | 160kDa |
| Synonyms: | LRIG1, LIG-1, LIG1 |
| Background: |
| UniProt Protein Function: | LRIG1: a singhle-pass type I membrane protein that acts as a feedback negative regulator of signaling by receptor tyrosine kinases. Regulates cadherin-dependent contact inhibition. Interacts with EGFR, HER2, -3, and -4. Two isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Protein kinase, regulatory subunit Chromosomal Location of Human Ortholog: 3p14.1 Cellular Component: plasma membrane |
| UniProt Code: | Q96JA1 |
| NCBI GenInfo Identifier: | 143811415 |
| NCBI Gene ID: | 26018 |
| NCBI Accession: | Q96JA1.2 |
| UniProt Secondary Accession: | Q96JA1,Q6IQ51, Q96CF9, Q9BYB8, Q9UFI4, |
| UniProt Related Accession: | Q96JA1 |
| Molecular Weight: | 119kDa |
| NCBI Full Name: | Leucine-rich repeats and immunoglobulin-like domains protein 1 |
| NCBI Synonym Full Names: | leucine rich repeats and immunoglobulin like domains 1 |
| NCBI Official Symbol: | LRIG1 |
| NCBI Official Synonym Symbols: | LIG1; LIG-1 |
| NCBI Protein Information: | leucine-rich repeats and immunoglobulin-like domains protein 1 |
| UniProt Protein Name: | Leucine-rich repeats and immunoglobulin-like domains protein 1 |
| Protein Family: | Leucine-rich repeats and immunoglobulin-like domains protein |
| UniProt Gene Name: | LRIG1 |
 | Western blot analysis of extracts of various cell lines, using LRIG1 antibody (CAB10297) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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