Name: Anti-LPIN2 Antibody (CAB15762)
Brand: Metabolism Antibodies 1
SKU: CAB15762
Availability: OutOfStock

Antibody Name:	Anti-LPIN2 Antibody
Antibody SKU:	CAB15762
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 180-400 of human LPIN2 (NP_055461.1).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human, Mouse
Positive Samples:	LO2, 293T, A-549, DU145, Mouse liver, Mouse lung, Mouse kidney, Mouse spleen

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 180-400 of human LPIN2 (NP_055461.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	TCDV GVSS DDDK GAQA ARGS SNAS LKEE ECKE PLLF HSGD HYPL SDGD WSPL ETTY PQTA CPKS DSEL EVKP AESL LRSE SHME WTWG GFPE STKV SKRE RSDH HPRT ATIT PSEN THFR VIPS EDNL ISEV EKDA SMED TVCT IVKP KPRA LGTQ MSDP TSVA ELLE PPLE STQI SSML DADH LPNA ALAE APSE SKPA AKVD SPSK KKGV HKRS QHQG P
Gene ID:	9663
Uniprot:	Q92539
Cellular Location:	Cytoplasm, Endoplasmic reticulum membrane, Nucleus, cytosol
Calculated MW:	99kDa
Observed MW:	110kDa

Synonyms:	LPIN2, lipin 2
Background:	Mouse studies suggest that this gene functions during normal adipose tissue development and may play a role in human triglyceride metabolism. This gene represents a candidate gene for human lipodystrophy, characterized by loss of body fat, fatty liver, hypertriglyceridemia, and insulin resistance.

UniProt Protein Function:	LPIN2: Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism. Defects in LPIN2 are the cause of Majeed syndrome (MAJEEDS). An autosomal recessive syndrome characterized by chronic recurrent multifocal osteomyelitis that is of early onset with a lifelong course, congenital dyserythropoietic anemia that presents as hypochromic, microcytic anemia during the first year of life and ranges from mild to transfusion-dependent, and transient inflammatory dermatosis, often manifesting as Sweet syndrome (neutrophilic skin infiltration). Belongs to the lipin family.
UniProt Protein Details:	Protein type:EC 3.1.3.4; Phosphatase (non-protein); Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 18p11.31 Cellular Component: cytosol; endoplasmic reticulum membrane; nucleus Molecular Function:phosphatidate phosphatase activity; transcription coactivator activity Biological Process: fatty acid catabolic process; lipid metabolic process; phosphatidylcholine biosynthetic process; phosphatidylethanolamine biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; triacylglycerol biosynthetic process Disease: Majeed Syndrome
NCBI Summary:	Mouse studies suggest that this gene functions during normal adipose tissue development and may play a role in human triglyceride metabolism. This gene represents a candidate gene for human lipodystrophy, characterized by loss of body fat, fatty liver, hypertriglyceridemia, and insulin resistance. [provided by RefSeq, Jul 2008]
UniProt Code:	Q92539
NCBI GenInfo Identifier:	2495724
NCBI Gene ID:	9663
NCBI Accession:	Q92539.1
UniProt Secondary Accession:	Q92539,A7MD25, D3DUH3,
UniProt Related Accession:	Q92539
Molecular Weight:	99,399 Da
NCBI Full Name:	Phosphatidate phosphatase LPIN2
NCBI Synonym Full Names:	lipin 2
NCBI Official Symbol:	LPIN2
NCBI Protein Information:	phosphatidate phosphatase LPIN2
UniProt Protein Name:	Phosphatidate phosphatase LPIN2
UniProt Synonym Protein Names:	Lipin-2
Protein Family:	Phosphatidate phosphatase
UniProt Gene Name:	LPIN2
UniProt Entry Name:	LPIN2_HUMAN

Western blot analysis of extracts of various cell lines, using LPIN2 antibody (CAB15762) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s.

Antibodies

LPIN2 Antibody (PACO10283)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)