Metabolism Antibodies 2
Anti-LPCAT1 Antibody (CAB4987)
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- SKU:
- CAB4987
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- LPCAT1
- Synonyms:
- AGPAT10
- Synonyms:
- AGPAT9
- Synonyms:
- AYTL2
- Synonyms:
- LPCAT-1
- Synonyms:
- PFAAP3
- Synonyms:
- lpcat
- Synonyms:
- lysoPAFAT
- Research Area:
- Metabolism
Description
| Product Name: | LPCAT1 Rabbit pAb |
| Product Code: | CAB4987 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | LPCAT1, AGPAT10, AGPAT9, AYTL2, LPCAT-1, PFAAP3, lpcat, lysoPAFAT |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 325-534 of human LPCAT1 (NP_079106.3). |
| Applications: | WB, IHC |
| Recommended Dilutions: | WB 1:1000 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | BT-474, 22Rv1, Hela, A-549, Mouse lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 325-534 of human LPCAT1 (NP_079106.3). |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LPAD TCLL EFAR LVRG LGLK PEKL EKDL DRYS ERAR MKGG EKIG IAEF AASL EVPV SDLL EDMF SLFD ESGS GEVD LREC VVAL SVVC RPAR TLDT IQLA FKMY GAQE DGSV GEGD LSCI LKTA LGVA ELTV TDLF RAID QEEK GKIT FADF HRFA EMYP AFAE EYLY PDQT HFES CAET SPAP IPNG FCAD FSPE NSDA GRKP VRKK LD |
| Gene ID: | 79888 |
| Uniprot: | Q8NF37 |
| Cellular Location: | Endoplasmic reticulum membrane, Golgi apparatus membrane, Lipid droplet, Single-pass type II membrane protein |
| Calculated MW: | 59kDa |
| Observed MW: | 59kDa |
| UniProt Protein Function: | LPCAT1: Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-independent. Mediates the conversion of 1-acyl-sn-glycero-3-phosphocholine (LPC) into phosphatidylcholine (PC). Displays a clear preference for saturated fatty acyl-CoAs, and 1-myristoyl or 1-palmitoyl LPC as acyl donors and acceptors, respectively. May synthesize phosphatidylcholine in pulmonary surfactant, thereby playing a pivotal role in respiratory physiology. Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. |
| UniProt Protein Details: | Protein type:EC 2.3.1.67; Acetyltransferase; Membrane protein, integral; EC 2.3.1.23; Endoplasmic reticulum Chromosomal Location of Human Ortholog: 5p15.33 Cellular Component: Golgi membrane; Golgi apparatus; endoplasmic reticulum membrane; membrane; endoplasmic reticulum; integral to membrane; lipid particle Molecular Function:1-alkylglycerophosphocholine O-acetyltransferase activity; 1-acylglycerophosphocholine O-acyltransferase activity; 1-alkenylglycerophosphocholine O-acyltransferase activity; 1-alkylglycerophosphocholine O-acyltransferase activity; calcium ion binding Biological Process: retina development in camera-type eye; phospholipid metabolic process; glycerophospholipid biosynthetic process; positive regulation of protein catabolic process; phosphatidic acid biosynthetic process; triacylglycerol biosynthetic process; cellular lipid metabolic process; surfactant homeostasis; phospholipid biosynthetic process |
| NCBI Summary: | Lysophosphatidylcholine (LPC) acyltransferase (LPCAT; EC 2.3.1.23) catalyzes the conversion of LPC to phosphatidylcholine (PC) in the remodeling pathway of PC biosynthesis (Nakanishi et al., 2006 [PubMed 16704971]).[supplied by OMIM, May 2008] |
| UniProt Code: | Q8NF37 |
| NCBI GenInfo Identifier: | 110815902 |
| NCBI Gene ID: | 79888 |
| NCBI Accession: | Q8NF37.2 |
| UniProt Secondary Accession: | Q8NF37,Q1HAQ1, Q7Z4G6, Q8N3U7, Q8WUL8, Q9GZW6, |
| UniProt Related Accession: | Q8NF37 |
| Molecular Weight: | Calculated MW: 59kDaObserved MW:59kDa |
| NCBI Full Name: | Lysophosphatidylcholine acyltransferase 1 |
| NCBI Synonym Full Names: | lysophosphatidylcholine acyltransferase 1 |
| NCBI Official Symbol: | LPCAT1 |
| NCBI Official Synonym Symbols: | AYTL2; lpcat; PFAAP3 |
| NCBI Protein Information: | lysophosphatidylcholine acyltransferase 1; LPCAT-1; lysoPAFAT; LPC acyltransferase 1; acyltransferase like 2; acyltransferase-like 2; lysoPC acyltransferase 1; lyso-PAF acetyltransferase; regulated by phosphonoformate; acetyl-CoA:lyso-PAF acetyltransferase; phosphonoformate immuno-associated protein 3; 1-acylglycerophosphocholine O-acyltransferase; 1-alkylglycerophosphocholine O-acetyltransferase; acyl-CoA:lysophosphatidylcholine acyltransferase 1; acetyl-CoA:lyso-platelet-activating factor acetyltransferase |
| UniProt Protein Name: | Lysophosphatidylcholine acyltransferase 1 |
| UniProt Synonym Protein Names: | 1-acylglycerophosphocholine O-acyltransferase; 1-alkylglycerophosphocholine O-acetyltransferase (EC:2.3.1.67); Acetyl-CoA:lyso-platelet-activating factor acetyltransferase; Acetyl-CoA:lyso-PAF acetyltransferase; Lyso-PAF acetyltransferase; LysoPAFAT; Acyltransferase-like 2; Phosphonoformate immuno-associated protein 3 |
| Protein Family: | Lysophosphatidylcholine acyltransferase |
| UniProt Gene Name: | LPCAT1 |
| UniProt Entry Name: | PCAT1_HUMAN |
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