Cell Biology Antibodies 5
Anti-LPAR2 Antibody (CAB14819)
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- SKU:
- CAB14819
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-LPAR2 Antibody |
| Antibody SKU: | CAB14819 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 250-350 of human LPAR2 (NP_004711.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | HL-60 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 250-350 of human LPAR2 (NP_004711.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | FVVC WTPG QVVL LLDG LGCE SCNV LAVE KYFL LLAE ANSL VNAA VYSC RDAE MRRT FRRL LCCA CLRQ STRE SVHY TSSA QGGA STRI MLPE NGHP LMDS T |
| Gene ID: | 9170 |
| Uniprot: | Q9HBW0 |
| Cellular Location: | Cell membrane, Cell surface, Multi-pass membrane protein |
| Calculated MW: | 39kDa |
| Observed MW: | 38kDa |
| Synonyms: | LPAR2, EDG-4, EDG4, LPA-2, LPA2 |
| Background: | This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins. An alternative splice variant has been described but its full length sequence has not been determined. |
| UniProt Protein Function: | EDG4: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation. Belongs to the G-protein coupled receptor 1 family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR Chromosomal Location of Human Ortholog: 19p12 Cellular Component: cell surface; endocytic vesicle; integral to plasma membrane; plasma membrane Molecular Function:G-protein coupled receptor activity; lipid binding; protein binding Biological Process: elevation of cytosolic calcium ion concentration; phospholipase C activation |
| NCBI Summary: | This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9HBW0 |
| NCBI GenInfo Identifier: | 26393399 |
| NCBI Gene ID: | 9170 |
| NCBI Accession: | Q9HBW0.2 |
| UniProt Secondary Accession: | Q9HBW0,O00543, O43431, |
| UniProt Related Accession: | Q9HBW0 |
| Molecular Weight: | 39,084 Da |
| NCBI Full Name: | Lysophosphatidic acid receptor 2 |
| NCBI Synonym Full Names: | lysophosphatidic acid receptor 2 |
| NCBI Official Symbol: | LPAR2 |
| NCBI Official Synonym Symbols: | EDG4; LPA2; EDG-4; LPA-2 |
| NCBI Protein Information: | lysophosphatidic acid receptor 2 |
| UniProt Protein Name: | Lysophosphatidic acid receptor 2 |
| UniProt Synonym Protein Names: | Lysophosphatidic acid receptor Edg-4 |
| Protein Family: | Lysophosphatidic acid receptor |
| UniProt Gene Name: | LPAR2 |
| UniProt Entry Name: | LPAR2_HUMAN |
 | Western blot analysis of extracts of HL-60 cells, using LPAR2 antibody (CAB14819) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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