Signal Transduction Antibodies 1
Anti-LOXL4 Antibody (CAB13131)
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- SKU:
- CAB13131
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-LOXL4 Antibody |
| Antibody SKU: | CAB13131 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-280 of human LOXL4 (NP_115587.6). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | BxPC-3 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-280 of human LOXL4 (NP_115587.6). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | QSLG TTKL RLVG PESK PEEG RLEV LHQG QWGT VCDD NFAI QEAT VACR QLGF EAAL TWAH SAKY GQGE GPIW LDNV RCVG TESS LDQC GSNG WGVS DCSH SEDV GVIC HPRR HRGY LSET VSNA LGPQ GRRL EEVR LKPI LASA KQHS PVTE GAVE VKYE GHWR QVCD QGWT MNNS RVVC GMLG FPSE VPVD SHYY RKVW DLKM RDPK SRLK SLTN KNSF WIHQ VTCL GTEP HMAN CQVQ VAPA RGKL RPAC PGGM |
| Gene ID: | 84171 |
| Uniprot: | Q96JB6 |
| Cellular Location: | Secreted, extracellular space |
| Calculated MW: | 84kDa |
| Observed MW: | 84kDa |
| Synonyms: | LOXL4, LOXC |
| Background: | This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. |
| UniProt Protein Function: | LOXL4: May modulate the formation of a collagenous extracellular matrix. Belongs to the lysyl oxidase family. |
| UniProt Protein Details: | Protein type:EC 1.4.3.-; Secreted; Secreted, signal peptide; Oxidoreductase Chromosomal Location of Human Ortholog: 10q24 Cellular Component: receptor complex Molecular Function:protein binding |
| NCBI Summary: | This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q96JB6 |
| NCBI GenInfo Identifier: | 20177960 |
| NCBI Gene ID: | 84171 |
| NCBI Accession: | Q96JB6.1 |
| UniProt Secondary Accession: | Q96JB6,Q5W0B3, Q96DY1, Q96PC0, Q9H6T5, |
| UniProt Related Accession: | Q96JB6 |
| Molecular Weight: | 84,483 Da |
| NCBI Full Name: | Lysyl oxidase homolog 4 |
| NCBI Synonym Full Names: | lysyl oxidase like 4 |
| NCBI Official Symbol: | LOXL4 |
| NCBI Official Synonym Symbols: | LOXC |
| NCBI Protein Information: | lysyl oxidase homolog 4 |
| UniProt Protein Name: | Lysyl oxidase homolog 4 |
| UniProt Synonym Protein Names: | Lysyl oxidase-like protein 4; Lysyl oxidase-related protein C |
| Protein Family: | Lysyl oxidase |
| UniProt Gene Name: | LOXL4 |
| UniProt Entry Name: | LOXL4_HUMAN |
 | Western blot analysis of extracts of BxPC-3 cells, using LOXL4 antibody (CAB13131) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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