Cell Biology Antibodies 11
Anti-LOX Antibody (CAB7698)
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- SKU:
- CAB7698
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-LOX Antibody |
| Antibody SKU: | CAB7698 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide of human LOX |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, Jurkat, A-431, Mouse heart, Mouse skeletal muscle, Mouse skin, Rat lung |
| Immunogen: | A synthetic peptide of human LOX |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 4015 |
| Uniprot: | P28300 |
| Cellular Location: | Secreted, extracellular space |
| Calculated MW: | 46kDa |
| Observed MW: | 38kDa |
| Synonyms: | LOX, AAT10 |
| Background: | This gene encodes a member of the lysyl oxidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a regulatory propeptide and the mature enzyme. The copper-dependent amine oxidase activity of this enzyme functions in the crosslinking of collagens and elastin, while the propeptide may play a role in tumor suppression. In addition, defects in this gene have been linked with predisposition to thoracic aortic aneurysms and dissections. |
| UniProt Protein Function: | LOX: Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression. Belongs to the lysyl oxidase family. |
| UniProt Protein Details: | Protein type:EC 1.4.3.13; Secreted; Secreted, signal peptide; Oxidoreductase Chromosomal Location of Human Ortholog: 5q23.2 Cellular Component: extracellular region Molecular Function:protein binding Biological Process: extracellular matrix organization and biogenesis; protein modification process Disease: Cutis Laxa, Autosomal Recessive, Type Ia |
| NCBI Summary: | This gene encodes a member of the lysyl oxidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a regulatory propeptide and the mature enzyme. The copper-dependent amine oxidase activity of this enzyme functions in the crosslinking of collagens and elastin, while the propeptide may play a role in tumor suppression. In addition, defects in this gene have been linked with predisposition to thoracic aortic aneurysms and dissections. [provided by RefSeq, Jul 2016] |
| UniProt Code: | P28300 |
| NCBI GenInfo Identifier: | 417269 |
| NCBI Gene ID: | 4015 |
| NCBI Accession: | P28300.2 |
| UniProt Secondary Accession: | P28300,Q5FWF0, B2R5Q3, |
| UniProt Related Accession: | P28300 |
| Molecular Weight: | 46,944 Da |
| NCBI Full Name: | Protein-lysine 6-oxidase |
| NCBI Synonym Full Names: | lysyl oxidase |
| NCBI Official Symbol: | LOX |
| NCBI Protein Information: | protein-lysine 6-oxidase |
| UniProt Protein Name: | Protein-lysine 6-oxidase |
| UniProt Synonym Protein Names: | Lysyl oxidase |
| Protein Family: | Linoleate 9/13-lipoxygenase |
| UniProt Gene Name: | LOX |
| UniProt Entry Name: | LYOX_HUMAN |
 | Western blot analysis of extracts of various cell lines, using LOX antibody (CAB7698) at 1:500 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 90s. |
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