Cell Biology Antibodies 6

Anti-LONP2 Antibody (CAB15909)

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SKU:
CAB15909
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-LONP2 Antibody
Antibody SKU:CAB15909
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human LONP2 (NP_113678.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:U-87MG, HeLa, A-375, Mouse kidney, Mouse liver, Mouse lung, Rat testis
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human LONP2 (NP_113678.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MSSV SPIQ IPSR LPLL LTHE GVLL PGST MRTS VDSA RNLQ LVRS RLLK GTSL QSTI LGVI PNTP DPAS DAQD LPPL HRIG TAAL AVQV VGSN WPKP HYTL LITG LCRF QIVQ VLKE KPYP IAEV EQLD RLEE FPNT CKMR EELG ELSE QFYK YAVQ LVEM LDMS VPAV AKLR RLLD SLPR EALP DILT SIIR TSNK EKLQ ILDA VSLE ERFK MTIP LLVR QIEG LKLL QKTR KPKQ DDDK RVIA IRPI RRIT HISG TLED EDED EDND DIVM LEKK IRTS SMPE QAHK VCVK EIKR LKKM
Gene ID:83752
Uniprot:Q86WA8
Cellular Location:Peroxisome matrix
Calculated MW:89kDa/94kDa
Observed MW:110kDa
Synonyms:LONP2, LONP, LONPL, PLON, PSLON
Background:In human, peroxisomes function primarily to catalyze fatty acid beta-oxidation and, as a by-product, produce hydrogen peroxide and superoxide. The protein encoded by this gene is an ATP-dependent protease that likely plays a role in maintaining overall peroxisome homeostasis as well as proteolytically degrading peroxisomal proteins damaged by oxidation. The protein has an N-terminal Lon N substrate recognition domain, an ATPase domain, a proteolytic domain, and, in some isoforms, a C-terminal peroxisome targeting sequence. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
UniProt Protein Function:LONP2: ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1. Belongs to the peptidase S16 family.
UniProt Protein Details:

Protein type:Protease; EC 3.4.21.-

Chromosomal Location of Human Ortholog: 16q12.1

Cellular Component: membrane; peroxisomal matrix; peroxisome

Molecular Function:ATP-dependent peptidase activity; enzyme binding; peptidase activity; protease binding; protein binding; receptor binding

Biological Process: misfolded or incompletely synthesized protein catabolic process; protein processing; protein targeting to peroxisome; regulation of fatty acid beta-oxidation

UniProt Code:Q86WA8
NCBI GenInfo Identifier:74727668
NCBI Gene ID:83752
NCBI Accession:Q86WA8.1
UniProt Secondary Accession:Q86WA8,Q0D2H6, Q8N3B9, Q8NCE9, Q96K43, B7ZKL7,
UniProt Related Accession:Q86WA8
Molecular Weight:89,660 Da
NCBI Full Name:Lon protease homolog 2, peroxisomal
NCBI Synonym Full Names:lon peptidase 2, peroxisomal
NCBI Official Symbol:LONP2  
NCBI Official Synonym Symbols:LONP; LONPL  
NCBI Protein Information:lon protease homolog 2, peroxisomal
UniProt Protein Name:Lon protease homolog 2, peroxisomal
UniProt Synonym Protein Names:Lon protease-like protein 2
UniProt Gene Name:LONP2  
UniProt Entry Name:LONP2_HUMAN
Anti-LONP2 Antibody (CAB15909)Western blot analysis of extracts of various cell lines, using LONP2 antibody (CAB15909) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.
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