Epigenetics & Nuclear Signaling Antibodies 3
Anti-LMX1B Antibody (CAB14021)
(No reviews yet)
Write a Review
- SKU:
- CAB14021
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-LMX1B Antibody |
| Antibody SKU: | CAB14021 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human LMX1B (NP_001167618.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | BT-474, BxPC-3, HeLa, Mouse liver, Mouse heart, Rat brain |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human LMX1B (NP_001167618.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MDIA TGPE SLER CFPR GQTD CAKM LDGI KMEE HALR PGPA TLGV LLGS DCPH PAVC EGCQ RPIS DRFL MRVN ESSW HEEC LQCA ACQQ ALTT SCYF RDRK |
| Gene ID: | 4010 |
| Uniprot: | O60663 |
| Cellular Location: | Nucleus |
| Calculated MW: | 44kDa/45kDa |
| Observed MW: | 45kDa |
| Synonyms: | LMX1B, LMX1.2, NPS1 |
| Background: | This gene encodes a member of LIM-homeodomain family of proteins containing two N-terminal zinc-binding LIM domains, 1 homeodomain, and a C-terminal glutamine-rich domain. It functions as a transcription factor, and is essential for the normal development of dorsal limb structures, the glomerular basement membrane, the anterior segment of the eye, and dopaminergic and serotonergic neurons. Mutations in this gene are associated with nail-patella syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | LMX1B: Essential for the specification of dorsal limb fate at both the zeugopodal and autopodal levels. Defects in LMX1B are the cause of nail-patella syndrome (NPS); also known as onychoosteodysplasia. NPS is a disease that cause abnormal skeletal patterning and renal dysplasia. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell development/differentiation; DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 9q33.3 Cellular Component: nucleus Molecular Function:protein binding; zinc ion binding; sequence-specific DNA binding; transcription factor activity Biological Process: collagen fibril organization; transcription, DNA-dependent; in utero embryonic development; multicellular organismal development; neuron migration; cerebellum morphogenesis; limb morphogenesis; neuron differentiation; cell proliferation; organ growth; regulation of transcription, DNA-dependent; dorsal/ventral pattern formation; midbrain development; positive regulation of transcription from RNA polymerase II promoter; central nervous system neuron development Disease: Nail-patella Syndrome |
| NCBI Summary: | This gene encodes a member of LIM-homeodomain family of proteins containing two N-terminal zinc-binding LIM domains, 1 homeodomain, and a C-terminal glutamine-rich domain. It functions as a transcription factor, and is essential for the normal development of dorsal limb structures, the glomerular basement membrane, the anterior segment of the eye, and dopaminergic and serotonergic neurons. Mutations in this gene are associated with nail-patella syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010] |
| UniProt Code: | O60663 |
| NCBI GenInfo Identifier: | 485956425 |
| NCBI Gene ID: | 4010 |
| NCBI Accession: | O60663.3 |
| UniProt Secondary Accession: | O60663,O75463, Q5JU95, Q6ISC9, F8W7W6, |
| UniProt Related Accession: | O60663 |
| Molecular Weight: | 402 |
| NCBI Full Name: | LIM homeobox transcription factor 1-beta |
| NCBI Synonym Full Names: | LIM homeobox transcription factor 1, beta |
| NCBI Official Symbol: | LMX1B |
| NCBI Official Synonym Symbols: | NPS1; LMX1.2 |
| NCBI Protein Information: | LIM homeobox transcription factor 1-beta; LMX-1.2; LIM/homeobox protein 1.2; LIM/homeobox protein LMX1B |
| UniProt Protein Name: | LIM homeobox transcription factor 1-beta |
| UniProt Synonym Protein Names: | LIM/homeobox protein 1.2; LMX-1.2; LIM/homeobox protein LMX1B |
| Protein Family: | LIM/homeobox protein |
| UniProt Gene Name: | LMX1B |
| UniProt Entry Name: | LMX1B_HUMAN |
 | Western blot analysis of extracts of various cell lines, using LMX1B antibody (CAB14021) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
View AllClose
Related Products
