Cell Biology Antibodies 6

Anti-LMTK2 Antibody (CAB15403)

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SKU:
CAB15403
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-LMTK2 Antibody
Antibody SKU:CAB15403
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1100-1300 of human LMTK2 (NP_055731.2).
Application:WB
Recommended Dilution:WB 1:200 - 1:2000
Reactivity:Human
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1100-1300 of human LMTK2 (NP_055731.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:YRDS AYFS DNDS EPEK RSEE VPGT SPSA LVLV QEQP LPEP VLPE QSPA AQDS CLEA RKSQ PDES CLSA LHNS SDLE LRAT PEPA QTGV PQQV HPTE DEAS SPWS VLNA ELSS GDDF ETQD DRPC TLAS TGTN TNEL LAYT NSAL DKSL SSHS EGPK LKEP DIEG KYLG KLGV SGML DLSE DGMD ADEE DENS DDSD EDLR A
Gene ID:22853
Uniprot:Q8IWU2
Cellular Location:Membrane, Multi-pass membrane protein
Calculated MW:164kDa
Observed MW:Refer to figures
Synonyms:LMTK2, AATYK2, BREK, KPI-2, KPI2, LMR2, PPP1R100, cprk, hBREK
Background:The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis.
UniProt Protein Function:Lmr2: a tyrosine kinase of the Lmr family that apparently phosphorylates Serine and Threonine residues. Associates with PP1C and Inh2 to form a regulatory complex that localizes to membranes. Enriched in brain and muscle. Inhibited in living cells by addition of nerve growth factor or serum. Appears to be inhibited by Cdk5/p35.
UniProt Protein Details:

Protein type:EC 2.7.11.1; Protein kinase, TK; Membrane protein, multi-pass; Kinase, protein; Membrane protein, integral; Protein kinase, tyrosine (receptor); TK group; Lmr family

Chromosomal Location of Human Ortholog: 7q21.3

Cellular Component: early endosome; Golgi apparatus; integral to membrane; perinuclear region of cytoplasm; recycling endosome

Molecular Function:protein binding; protein phosphatase inhibitor activity; protein serine/threonine kinase activity

Biological Process: early endosome to late endosome transport; endocytic recycling; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; protein amino acid autophosphorylation; protein amino acid phosphorylation; receptor recycling; transferrin transport

NCBI Summary:The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis. [provided by RefSeq, Oct 2009]
UniProt Code:Q8IWU2
NCBI GenInfo Identifier:145559492
NCBI Gene ID:22853
NCBI Accession:Q8IWU2.2
UniProt Secondary Accession:Q8IWU2,Q75MG7, Q9UPS3, A4D272,
UniProt Related Accession:Q8IWU2
Molecular Weight:164,900 Da
NCBI Full Name:Serine/threonine-protein kinase LMTK2
NCBI Synonym Full Names:lemur tyrosine kinase 2
NCBI Official Symbol:LMTK2  
NCBI Official Synonym Symbols:BREK; KPI2; LMR2; cprk; KPI-2; hBREK; AATYK2; PPP1R100  
NCBI Protein Information:serine/threonine-protein kinase LMTK2
UniProt Protein Name:Serine/threonine-protein kinase LMTK2
UniProt Synonym Protein Names:Apoptosis-associated tyrosine kinase 2; Brain-enriched kinase; hBREK; CDK5/p35-regulated kinase; CPRK; Kinase/phosphatase/inhibitor 2; Lemur tyrosine kinase 2; Serine/threonine-protein kinase KPI-2
Protein Family:Serine/threonine-protein kinase
UniProt Gene Name:LMTK2  
UniProt Entry Name:LMTK2_HUMAN
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