Anti-LMO2 Antibody (CAB6832)
- SKU:
- CAB6832
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- RBTN2
- Synonyms:
- RBTNL1
- Synonyms:
- RHOM2
- Synonyms:
- TTG2
- Research Area:
- Cell Biology
Description
| Product Name: | LMO2 Rabbit mAb |
| Product Code: | CAB6832 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | RBTN2, RBTNL1, RHOM2, TTG2 |
| Applications: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human LMO2 |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | K-562, U-87MG |
| Immunogen: | A synthesized peptide derived from human LMO2 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 4005 |
| Uniprot: | P25791 |
| Calculated MW: | 18kDa |
| Observed MW: | 18KDa |
| UniProt Protein Function: | LMO2: Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state. A chromosomal aberration involving LMO2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(11,14)(p13;q11) with TCRD. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold; Oncoprotein Chromosomal Location of Human Ortholog: 11p13 Cellular Component: transcription factor complex; nucleus Molecular Function:protein binding; zinc ion binding; bHLH transcription factor binding; chromatin binding; cofactor binding Biological Process: negative regulation of erythrocyte differentiation; embryonic hemopoiesis; multicellular organismal development; positive regulation of transcription from RNA polymerase II promoter; mRNA transcription from RNA polymerase II promoter |
| NCBI Summary: | LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Nov 2008] |
| UniProt Code: | P25791 |
| NCBI GenInfo Identifier: | 132533 |
| NCBI Gene ID: | 4005 |
| NCBI Accession: | P25791.1 |
| UniProt Related Accession: | P25791 |
| Molecular Weight: | 18.4kDa |
| NCBI Full Name: | Rhombotin-2 |
| NCBI Synonym Full Names: | LIM domain only 2 |
| NCBI Official Symbol: | LMO2 |
| NCBI Official Synonym Symbols: | TTG2; LMO-2; RBTN2; RHOM2; RBTNL1 |
| NCBI Protein Information: | rhombotin-2 |
| UniProt Protein Name: | Rhombotin-2 |
| UniProt Synonym Protein Names: | Cysteine-rich protein TTG-2; LIM domain only protein 2; LMO-2; T-cell translocation protein 2 |
| Protein Family: | Rhombotin |
| UniProt Gene Name: | LMO2 |
| UniProt Entry Name: | RBTN2_HUMAN |
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