Cell Biology Antibodies 14
Anti-LMNB1 Antibody (CAB16910)
(No reviews yet)
Write a Review
- SKU:
- CAB16910
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-LMNB1 Antibody |
| Antibody SKU: | CAB16910 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human LMNB1. |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Jurkat, Mouse spleen, Rat liver |
| Immunogen: | Recombinant protein of human LMNB1. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 4001 |
| Uniprot: | P20700 |
| Cellular Location: | Lipid-anchor, Nucleoplasmic side, Nucleus inner membrane |
| Calculated MW: | 66kDa |
| Observed MW: | 68kDa |
 | Western blot - LMNB1 Rabbit pAb (CAB16910) |
| Synonyms: | ADLD, LMN, LMN2, LMNB, Lamin B1, LMNB1, lamin-B1 |
| Background: | This gene encodes one of the two B-type lamin proteins and is a component of the nuclear lamina. A duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | Lamin B1: nuclear lamins are intermediate filament proteins that constitute the lattice-like matrix at the inner face of the nuclear membrane that underlies the nuclear envelop. The lamins, highly conserved throughout evolution, are encoded by three genes in the human: LMNA, LMNB1, and LMNB2. The A-type lamins (lamin A/C) are developmentally regulated and are generally expressed in differentiated cells. The anchoring of chromatin to the nuclear lamina is involved in the control of gene expression and in DNA replication and repair. During mitosis, the nuclear lamina is reversibly disassembled as the lamin proteins are phosphorylated. B-type lamins are phosphorylated within minutes of engaging the IgM surface receptor of resting splenic B cells. Nuclear lamins are cleaved by caspases during apoptosis. |
| UniProt Protein Details: | Protein type:Cytoskeletal Chromosomal Location of Human Ortholog: 5q23.2 Cellular Component: nucleoplasm; nuclear membrane; membrane; lamin filament; nuclear inner membrane; nuclear envelope Molecular Function:phospholipase binding; structural molecule activity Biological Process: apoptosis; cell structure disassembly during apoptosis Disease: Leukodystrophy, Demyelinating, Adult-onset, Autosomal Dominant |
| NCBI Summary: | This gene encodes one of the two B-type lamin proteins and is a component of the nuclear lamina. A duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015] |
| UniProt Code: | P20700 |
| NCBI GenInfo Identifier: | 125953 |
| NCBI Gene ID: | 4001 |
| NCBI Accession: | P20700.2 |
| UniProt Related Accession: | P20700 |
| Molecular Weight: | ~ 68kDa |
| NCBI Full Name: | Lamin-B1 |
| NCBI Synonym Full Names: | lamin B1 |
| NCBI Official Symbol: | LMNB1 |
| NCBI Official Synonym Symbols: | LMN; ADLD; LMN2; LMNB |
| NCBI Protein Information: | lamin-B1 |
| UniProt Protein Name: | Lamin-B1 |
| Protein Family: | Light-harvesting protein |
| UniProt Gene Name: | LMNB1 |
| UniProt Entry Name: | LMNB1_HUMAN |
Related Products
Human LMNB1 / Lamin B1 ELISA Kit
system_update_altDatasheet - तकनीकी मैनुअलsystem_update_altMSDS - तकनीक
Human anti-EPO antibody(anti-Erythropoietin antibody) ELISA Kit
system_update_altDatasheet - तकनीकी मैनुअलsystem_update_altMSDS - तकनीक
