Cell Biology Antibodies 6
Anti-LMAN2 Antibody (CAB15394)
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- SKU:
- CAB15394
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-LMAN2 Antibody |
| Antibody SKU: | CAB15394 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 190-320 of human LMAN2 (NP_006807.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:200 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse brain, Mouse heart, Mouse kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 190-320 of human LMAN2 (NP_006807.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | HSKD GRWT ELAG CTAD FRNR DHDT FLAV RYSR GRLT VMTD LEDK NEWK NCID ITGV RLPT GYYF GASA GTGD LSDN HDII SMKL FQLM VEHT PDEE SIDW TKIE PSVN FLKS PKDN VDDP TGNF RSGP LTG |
| Gene ID: | 10960 |
| Uniprot: | Q12907 |
| Cellular Location: | Endoplasmic reticulum membrane, Endoplasmic reticulum-Golgi intermediate compartment membrane, Golgi apparatus membrane, Single-pass membrane protein, Single-pass type I membrane protein |
| Calculated MW: | 40kDa |
| Observed MW: | 39kDa |
| Synonyms: | LMAN2, C5orf8, GP36B, VIP36, lectin |
| Background: | This gene encodes a type I transmembrane lectin that shuttles between the endoplasmic reticulum, the Golgi apparatus and the plasma membrane. The encoded protein binds high mannose type glycoproteins and may facilitate their sorting, trafficking and quality control. |
| UniProt Protein Function: | LMAN2: Plays a role as an intracellular lectin in the early secretory pathway. Interacts with N-acetyl-D-galactosamine and high-mannose type glycans and may also bind to O-linked glycans. Involved in the transport and sorting of glycoproteins carrying high mannose-type glycans. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 5q35.3 Cellular Component: cell surface; ER-Golgi intermediate compartment; extracellular space; Golgi apparatus; integral to plasma membrane Molecular Function:carbohydrate binding; glycoprotein binding; heat shock protein binding; mannose binding Biological Process: positive regulation of phagocytosis; retrograde vesicle-mediated transport, Golgi to ER |
| NCBI Summary: | This gene encodes a type I transmembrane lectin that shuttles between the endoplasmic reticulum, the Golgi apparatus and the plasma membrane. The encoded protein binds high mannose type glycoproteins and may facilitate their sorting, trafficking and quality control. [provided by RefSeq, Oct 2008] |
| UniProt Code: | Q12907 |
| NCBI GenInfo Identifier: | 21264108 |
| NCBI Gene ID: | 10960 |
| NCBI Accession: | Q12907.1 |
| UniProt Secondary Accession: | Q12907,Q53HH1, |
| UniProt Related Accession: | Q12907 |
| Molecular Weight: | 40,229 Da |
| NCBI Full Name: | Vesicular integral-membrane protein VIP36 |
| NCBI Synonym Full Names: | lectin, mannose binding 2 |
| NCBI Official Symbol: | LMAN2 |
| NCBI Official Synonym Symbols: | GP36B; VIP36; C5orf8 |
| NCBI Protein Information: | vesicular integral-membrane protein VIP36 |
| UniProt Protein Name: | Vesicular integral-membrane protein VIP36 |
| UniProt Synonym Protein Names: | Glycoprotein GP36b; Lectin mannose-binding 2; Vesicular integral-membrane protein 36; VIP36 |
| Protein Family: | Vesicular integral-membrane protein |
| UniProt Gene Name: | LMAN2 |
| UniProt Entry Name: | LMAN2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using LMAN2 antibody (CAB15394) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
 | Immunofluorescence analysis of L929 cells using LMAN2 antibody (CAB15394) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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