Signal Transduction Antibodies 3
Anti-Lipocalin-1 Antibody (CAB9828)
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- SKU:
- CAB9828
- Product Type:
- Antibody
- Applications:
- WB
- Applications:
- IHC
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-Lipocalin-1 Antibody |
| Antibody SKU: | CAB9828 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 19-176 of human LCN1 (NP_002288.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
| Reactivity: | Human |
| Positive Samples: | HL-60, 293T |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 19-176 of human LCN1 (NP_002288.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | HHLL ASDE EIQD VSGT WYLK AMTV DREF PEMN LESV TPMT LTTL EGGN LEAK VTML ISGR CQEV KAVL EKTD EPGK YTAD GGKH VAYI IRSH VKDH YIFY CEGE LHGK PVRG VKLV GRDP KNNL EALE DFEK AAGA RGLS TESI LIPR QSET CSPG SD |
| Gene ID: | 3933 |
| Uniprot: | P31025 |
| Cellular Location: | Secreted |
| Calculated MW: | 19kDa |
| Observed MW: | 16kDa |
| Synonyms: | LCN1, PMFA, TLC, TP, VEGP |
| Background: | This gene encodes a member of the lipocalin family of small secretory proteins. Lipocalins are extracellular transport proteins that bind to a variety of hydrophobic ligands. The encoded protein is the primary lipid binding protein in tears and is overproduced in response to multiple stimuli including infection and stress. The encoded protein may be a marker for chromosome aneuploidy as well as an autoantigen in Sjogren's syndrome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and two pseudogenes of this gene are also located on the long arm of chromosome 9. |
| UniProt Protein Function: | LCN1: Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. Exhibits an extremely wide ligand pocket. Belongs to the calycin superfamily. Lipocalin family. |
| UniProt Protein Details: | Protein type:Secreted; Inhibitor; Secreted, signal peptide Chromosomal Location of Human Ortholog: 9q34 Cellular Component: extracellular space; extracellular region Molecular Function:cysteine protease inhibitor activity Biological Process: long-chain fatty acid transport; retinal homeostasis; sensory perception of taste; response to stimulus; proteolysis; transmembrane transport |
| NCBI Summary: | This gene encodes a member of the lipocalin family of small secretory proteins. Lipocalins are extracellular transport proteins that bind to a variety of hydrophobic ligands. The encoded protein is the primary lipid binding protein in tears and is overproduced in response to multiple stimuli including infection and stress. The encoded protein may be a marker for chromosome aneuploidy as well as an autoantigen in Sjogren's syndrome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and two pseudogenes of this gene are also located on the long arm of chromosome 9. [provided by RefSeq, Nov 2011] |
| UniProt Code: | P31025 |
| NCBI GenInfo Identifier: | 401346 |
| NCBI Gene ID: | 3933 |
| NCBI Accession: | P31025.1 |
| UniProt Related Accession: | P31025 |
| Molecular Weight: | |
| NCBI Full Name: | Lipocalin-1 |
| NCBI Synonym Full Names: | lipocalin 1 |
| NCBI Official Symbol: | LCN1 |
| NCBI Official Synonym Symbols: | TP; TLC; PMFA; VEGP |
| NCBI Protein Information: | lipocalin-1 |
| UniProt Protein Name: | Lipocalin-1 |
| UniProt Synonym Protein Names: | Tear lipocalin; Tlc; Tear prealbumin; TP; Von Ebner gland protein |
| Protein Family: | Lipocalin |
| UniProt Gene Name: | LCN1 |
| UniProt Entry Name: | LCN1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using LCN1 antibody (CAB9828) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded human prostate using LCN1 antibody (CAB9828) at dilution of 1:100 (40x lens). |
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