Metabolism Antibodies 1

Anti-LIPH Antibody (CAB15215)

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SKU:
CAB15215
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism

Description

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Antibody Name:Anti-LIPH Antibody
Antibody SKU:CAB15215
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 350-450 of human LIPH (NP_640341.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HT-29, DU145, 293T, BxPC-3, A-549, Mouse testis, Mouse lung, Rat testis
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 350-450 of human LIPH (NP_640341.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:KLRD KAGN TTES KINH EPTT FQKY HQVS LLAR FNQD LDKV AAIS LMFS TGSL IGPR YKLR ILRM KLRS LAHP ERPQ LCRY DLVL MENV ETVF QPIL CPEL Q
Gene ID:200879
Uniprot:Q8WWY8
Cellular Location:Membrane, Peripheral membrane protein, Secreted
Calculated MW:50kDa
Observed MW:54kDa
Synonyms:LIPH, AH, ARWH2, HYPT7, LAH2, LPDLR, PLA1B, mPA-PLA1, lipase H
Background:This gene encodes a membrane-bound member of the mammalian triglyceride lipase family. It catalyzes the production of 2-acyl lysophosphatidic acid (LPA), which is a lipid mediator with diverse biological properties that include platelet aggregation, smooth muscle contraction, and stimulation of cell proliferation and motility.
UniProt Protein Function:LIPH: Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG). Defects in LIPH are the cause of hypotrichosis type 7 (HYPT7); also known as alopecia universalis congenita Mari type. A condition characterized by the presence of less than the normal amount of hair. Affected individuals have sparse or absent scalp, axillary and body hair and sparse eyebrows and eyelashes. Defects in LIPH are the cause of woolly hair autosomal recessive type 2 (ARWH2). A hair shaft disorder characterized by fine and tightly curled hair. Compared to normal curly hair that is observed in some populations, woolly hair grows slowly and stops growing after a few inches. Under light microscopy, woolly hair shows some structural anomalies, including trichorrhexis nodosa and tapered ends. Some individuals may present with hypotrichosis. Belongs to the AB hydrolase superfamily. Lipase family.
UniProt Protein Details:

Protein type:Phospholipase; Secreted, signal peptide; Secreted; EC 3.1.1.-

Chromosomal Location of Human Ortholog: 3q27

Cellular Component: extracellular space; plasma membrane

Molecular Function:heparin binding; phospholipase activity

Biological Process: lipid catabolic process

Disease: Hypotrichosis 7

NCBI Summary:This gene encodes a membrane-bound member of the mammalian triglyceride lipase family. It catalyzes the production of 2-acyl lysophosphatidic acid (LPA), which is a lipid mediator with diverse biological properties that include platelet aggregation, smooth muscle contraction, and stimulation of cell proliferation and motility. [provided by RefSeq, Jul 2008]
UniProt Code:Q8WWY8
NCBI GenInfo Identifier:74762634
NCBI Gene ID:200879
NCBI Accession:Q8WWY8.1
UniProt Secondary Accession:Q8WWY8,Q8TEC7, A2IBA7,
UniProt Related Accession:Q8WWY8
Molecular Weight:50,859 Da
NCBI Full Name:Lipase member H
NCBI Synonym Full Names:lipase, member H
NCBI Official Symbol:LIPH  
NCBI Official Synonym Symbols:AH; LAH2; ARWH2; HYPT7; LPDLR; PLA1B; mPA-PLA1  
NCBI Protein Information:lipase member H; LPD lipase-related protein; lipase H; mPA-PLA1 alpha; membrane-associated phosphatidic acid-selective phospholipase A1-alpha; membrane-bound phosphatidic acid-selective phospholipase A1; phospholipase A1 member B
UniProt Protein Name:Lipase member H
UniProt Synonym Protein Names:LPD lipase-related protein; Membrane-associated phosphatidic acid-selective phospholipase A1-alpha; mPA-PLA1 alpha; Phospholipase A1 member B
Protein Family:Lipase
UniProt Gene Name:LIPH  
UniProt Entry Name:LIPH_HUMAN
Anti-LIPH Antibody (CAB15215)Western blot analysis of extracts of various cell lines, using LIPH antibody (CAB15215) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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