Metabolism Antibodies 3
Anti-LIPC Antibody (CAB1430)
- SKU:
- CAB1430
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-LIPC Antibody |
| Antibody SKU: | CAB1430 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 280-499 of human LIPC (NP_000227.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HepG2, HT-29, MCF7 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 280-499 of human LIPC (NP_000227.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ERSV HLFI DSLL HAGT QSMA YPCG DMNS FSQG LCLS CKKG RCNT LGYH VRQE PRSK SKRL FLVT RAQS PFKV YHYQ FKIQ FINQ TETP IQTT FTMS LLGT KEKM QKIP ITLG KGIA SNKT YSFL ITLD VDIG ELIM IKFK WENS AVWA NVWD TVQT IIPW STGP RHSG LVLK TIRV KAGE TQQR MTFC SENT DDLL LRPT QEKI FVKC EIKS KTSK RKIR |
| Gene ID: | 3990 |
| Uniprot: | P11150 |
| Cellular Location: | Secreted |
| Calculated MW: | 55kDa |
| Observed MW: | 55kDa |
 | Western blot - LIPC Polyclonal Antibody (CAB1430) |
| Synonyms: | LIPC, HDLCQ12, HL, HTGL, LIPH, lipase C |
| Background: | LIPC encodes hepatic triglyceride lipase, which is expressed in liver. LIPC has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. |
| UniProt Protein Function: | LIPC: Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin. Defects in LIPC are the cause of hepatic lipase deficiency (HL deficiency). A disorder characterized by elevated levels of beta-migrating very low density lipoproteins, and abnormally triglyceride-rich low and high density lipoproteins. Belongs to the AB hydrolase superfamily. Lipase family. |
| UniProt Protein Details: | Protein type:Secreted; EC 3.1.1.3; Secreted, signal peptide; Lipid Metabolism - glycerolipid; Phospholipase Chromosomal Location of Human Ortholog: 15q21-q23 Cellular Component: endoplasmic reticulum lumen; extracellular region; extracellular space Molecular Function:apolipoprotein binding; low-density lipoprotein binding; phospholipase activity; triacylglycerol lipase activity Biological Process: cholesterol homeostasis; fatty acid biosynthetic process; lipid digestion; reverse cholesterol transport; triacylglycerol catabolic process Disease: Diabetes Mellitus, Noninsulin-dependent; Hepatic Lipase Deficiency; High Density Lipoprotein Cholesterol Level Quantitative Trait Locus 12 |
| NCBI Summary: | LIPC encodes hepatic triglyceride lipase, which is expressed in liver. LIPC has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P11150 |
| NCBI GenInfo Identifier: | 317373430 |
| NCBI Gene ID: | 3990 |
| NCBI Accession: | P11150.3 |
| UniProt Secondary Accession: | P11150,O43571, P78529, Q99465, A2RUB4, A8K9B6, |
| UniProt Related Accession: | P11150 |
| Molecular Weight: | 55,914 Da |
| NCBI Full Name: | Hepatic triacylglycerol lipase |
| NCBI Synonym Full Names: | lipase C, hepatic type |
| NCBI Official Symbol: | LIPC |
| NCBI Official Synonym Symbols: | HL; HTGL; LIPH; HDLCQ12 |
| NCBI Protein Information: | hepatic triacylglycerol lipase |
| UniProt Protein Name: | Hepatic triacylglycerol lipase |
| UniProt Synonym Protein Names: | Lipase member C |
| Protein Family: | Spore germination lipase |
| UniProt Gene Name: | LIPC |
| UniProt Entry Name: | LIPC_HUMAN |
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