Cell Biology Antibodies 12

Anti-LINGO1 Antibody (CAB9369)

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SKU:
CAB9369
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-LINGO1 Antibody
Antibody SKU:CAB9369
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 42-240 of human LINGO1 (NP_116197.4).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:MCF7, A-549, K-562, Mouse testis, Mouse lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 42-240 of human LINGO1 (NP_116197.4).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:CPPR CECS AQDR AVLC HRKR FVAV PEGI PTET RLLD LGKN RIKT LNQD EFAS FPHL EELE LNEN IVSA VEPG AFNN LFNL RTLG LRSN RLKL IPLG VFTG LSNL TKLD ISEN KIVI LLDY MFQD LYNL KSLE VGDN DLVY ISHR AFSG LNSL EQLT LEKC NLTS IPTE ALSH LHGL IVLR LRHL NINA IRDY SFKR LYR
Gene ID:84894
Uniprot:Q96FE5
Cellular Location:Cell membrane, Single-pass type I membrane protein
Calculated MW:69kDa
Observed MW:70kDa
Synonyms:LINGO1, LERN1, LRRN6A, UNQ201
Background:
UniProt Protein Function:LINGO1: Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: 15q24.3

Cellular Component: plasma membrane

Molecular Function:epidermal growth factor receptor binding; protein binding

Biological Process: axonogenesis; negative regulation of axonogenesis; signal transduction

UniProt Code:Q96FE5
NCBI GenInfo Identifier:50263044
NCBI Gene ID:84894
NCBI Accession:NP_116197
UniProt Secondary Accession:Q96FE5,Q6NUK3, Q6UXM3, Q6VVG0, Q6VVG1, Q6VVG2, Q8N3K5 Q96K52, D3DW80,
UniProt Related Accession:Q96FE5
Molecular Weight:15.1kDa (133aa)
NCBI Full Name:leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform a
NCBI Synonym Full Names:leucine rich repeat and Ig domain containing 1
NCBI Official Symbol:LINGO1  
NCBI Official Synonym Symbols:LERN1; LRRN6A; UNQ201  
NCBI Protein Information:leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
UniProt Protein Name:Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
UniProt Synonym Protein Names:Leucine-rich repeat and immunoglobulin domain-containing protein 1; Leucine-rich repeat neuronal protein 1; Leucine-rich repeat neuronal protein 6A
UniProt Gene Name:LINGO1  
UniProt Entry Name:LIGO1_HUMAN
Anti-LINGO1 Polyclonal Antibody (CAB9369)Western blot analysis of extracts of various cell lines, using LINGO1 antibody (CAB9369) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.
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