Cell Biology Antibodies 13

Anti-LIMD1 Antibody (CAB17585)

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SKU:
CAB17585
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-LIMD1 Antibody
Antibody SKU:CAB17585
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human LIMD1 (NP_055055.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:MCF7, HeLa, HepG2, Mouse lung, Mouse heart
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human LIMD1 (NP_055055.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MDKY DDLG LEAS KFIE DLNM YEAS KDGL FRVD KGAG NNPE FEET RRVF ATKM AKIH LQQQ QQQL LQEE TLPR GSRG PVNG GGRL GPQA RWEV VGSK LTVD GAAK PPLA ASTG APGA VTTL AAGQ PPYP PQEQ RSRP YLHG TRHG SQDC GSRE SLAT SEMS AFHQ PGPC EDPS CLTH GDYY DNLS LASP KWGD KPGV SPSI
Gene ID:8994
Uniprot:Q9UGP4
Cellular Location:
Calculated MW:
Observed MW:72kDa
Anti-LIMD1 Antibody (CAB17585)Western blot - LIMD1 Polyclonal Antibody (CAB17585)
Synonyms:LIMD1
Background:
UniProt Protein Function:LIMD1: Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG- dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1- responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation. Belongs to the zyxin/ajuba family.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Tumor suppressor

Chromosomal Location of Human Ortholog: 3p21.3

Cellular Component: adherens junction; cytoplasm; focal adhesion; nucleus

Molecular Function:protein binding; transcription corepressor activity

Biological Process: cell migration; cytoplasmic mRNA processing body assembly; cytoskeleton organization and biogenesis; miRNA-mediated gene silencing; multicellular organismal development; negative regulation of osteoblast differentiation; negative regulation of transcription, DNA-dependent; osteoblast development; phosphorylation; regulation of cell shape; regulation of transcription, DNA-dependent; response to hypoxia; signal transduction

UniProt Code:Q9UGP4
NCBI GenInfo Identifier:47605932
NCBI Gene ID:8994
NCBI Accession:Q9UGP4.1
UniProt Secondary Accession:Q9UGP4,Q17RQ1, Q9BQQ9, Q9NQ47,
UniProt Related Accession:Q9UGP4
Molecular Weight:72,190 Da
NCBI Full Name:LIM domain-containing protein 1
NCBI Synonym Full Names:LIM domains containing 1
NCBI Official Symbol:LIMD1  
NCBI Protein Information:LIM domain-containing protein 1
UniProt Protein Name:LIM domain-containing protein 1
Protein Family:LIM domain-containing protein
UniProt Gene Name:LIMD1  
UniProt Entry Name:LIMD1_HUMAN
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