Immunology Antibodies 2
Anti-LILRB4 Antibody (CAB7073)
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- SKU:
- CAB7073
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-LILRB4 Antibody |
| Antibody SKU: | CAB7073 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-259 of human LILRB4 (NP_001265355.2). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A-549, MCF7, THP-1 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-259 of human LILRB4 (NP_001265355.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | QAGP LPKP TLWA EPGS VISW GNSV TIWC QGTL EARE YRLD KEES PAPW DRQN PLEP KNKA RFSI PSMT EDYA GRYR CYYR SPVG WSQP SDPL ELVM TGAY SKPT LSAL PSPL VTSG KSVT LLCQ SRSP MDTF LLIK ERAA HPLL HLRS EHGA QQHQ AEFP MSPV TSVH GGTY RCFS SHGF SHYL LSHP SDPL ELIV SGSL EGPR PSPT RSVS TAAG PEDQ PLMP TGSV PHSG LRRH WE |
| Gene ID: | 11006 |
| Uniprot: | Q8NHJ6 |
| Cellular Location: | Cell membrane, Single-pass type I membrane protein |
| Calculated MW: | 49kDa |
| Observed MW: | 49KDa |
| Synonyms: | LILRB4, CD85K, ILT-3, ILT3, LIR-5, LIR5 |
| Background: | This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | LILRB4: Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5- signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Receptor, misc.; Membrane protein, integral Chromosomal Location of Human Ortholog: 19q13.4 Cellular Component: integral to membrane; plasma membrane Molecular Function:protein binding; receptor activity; antigen binding Biological Process: negative regulation of osteoclast differentiation; immune system process; signal transduction |
| NCBI Summary: | This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8NHJ6 |
| NCBI GenInfo Identifier: | 322510117 |
| NCBI Gene ID: | 11006 |
| NCBI Accession: | Q8NHJ6.3 |
| UniProt Secondary Accession: | Q8NHJ6,O15468, O75021, Q6FGQ9, Q8N1C7, Q8NHL5, A8MVL8 |
| UniProt Related Accession: | Q8NHJ6 |
| Molecular Weight: | Calculated: 49 kDaObserved: 45-49kDa |
| NCBI Full Name: | Leukocyte immunoglobulin-like receptor subfamily B member 4 |
| NCBI Synonym Full Names: | leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4 |
| NCBI Official Symbol: | LILRB4 |
| NCBI Official Synonym Symbols: | ILT3; LIR5; CD85K; ILT-3; LIR-5 |
| NCBI Protein Information: | leukocyte immunoglobulin-like receptor subfamily B member 4; immunoglobulin-like transcript 3; CD85 antigen-like family member K; monocyte inhibitory receptor HM18; leukocyte immunoglobulin-like receptor 5 |
| UniProt Protein Name: | Leukocyte immunoglobulin-like receptor subfamily B member 4 |
| UniProt Synonym Protein Names: | CD85 antigen-like family member K; Immunoglobulin-like transcript 3; ILT-3; Leukocyte immunoglobulin-like receptor 5; LIR-5; Monocyte inhibitory receptor HM18; CD_antigen: CD85k |
| Protein Family: | Leukocyte immunoglobulin-like receptor subfamily |
| UniProt Gene Name: | LILRB4 |
| UniProt Entry Name: | LIRB4_HUMAN |
 | Western blot analysis of extracts of various cell lines, using LILRB4 antibody (CAB7073) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
 | Immunohistochemistry of paraffin-embedded human liver cancer using LILRB4 Rabbit pAb (CAB7073) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human colon carcinoma using LILRB4 Rabbit pAb (CAB7073) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of mouse spleen using LILRB4 Rabbit pAb (CAB7073) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
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