Immunology Antibodies 1
Anti-LILRB2 Antibody (CAB12157)
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- SKU:
- CAB12157
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-LILRB2 Antibody |
| Antibody SKU: | CAB12157 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 479-598 of human LILRB2 (NP_005865.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | THP-1, U-87MG |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 479-598 of human LILRB2 (NP_005865.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LFLI LRHR RQGK HWTS TQRK ADFQ HPAG AVGP EPTD RGLQ WRSS PAAD AQEE NLYA AVKD TQPE DGVE MDTR AAAS EAPQ DVTY AQLH SLTL RRKA TEPP PSQE REPP AEPS IYAT LAIH |
| Gene ID: | 10288 |
| Uniprot: | Q8N423 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 51kDa/55kDa/64kDa/65kDa |
| Observed MW: | 65kDa |
| Synonyms: | LILRB2, CD85D, ILT-4, ILT4, LIR-2, LIR2, MIR-10, MIR10 |
| Background: | This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | LILRB2: Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 19q13.4 Cellular Component: extracellular space; cell surface; membrane; integral to plasma membrane; cytoplasm; plasma membrane Molecular Function:protein binding; MHC class I protein binding; cell adhesion molecule binding; receptor activity; protein phosphatase 1 binding; inhibitory MHC class I receptor activity Biological Process: immune response-inhibiting cell surface receptor signaling pathway; negative regulation of calcium ion transport; regulation of immune response; positive regulation of regulatory T cell differentiation; negative regulation of immune response; positive regulation of interleukin-6 production; signal transduction; positive regulation of tolerance induction; heterotypic cell-cell adhesion; cell surface receptor linked signal transduction; negative regulation of T cell proliferation; cell-cell signaling; negative regulation of antigen processing and presentation; cellular defense response; positive regulation of T cell proliferation; Fc receptor mediated inhibitory signaling pathway; immune response; positive regulation of T cell tolerance induction |
| NCBI Summary: | This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8N423 |
| NCBI GenInfo Identifier: | 311033485 |
| NCBI Gene ID: | 10288 |
| NCBI Accession: | Q8N423.4 |
| UniProt Secondary Accession: | Q8N423,O75017, Q8NHJ7, Q8NHJ8, A8MU67, C9JF29, |
| UniProt Related Accession: | Q8N423 |
| Molecular Weight: | 51,959 Da |
| NCBI Full Name: | Leukocyte immunoglobulin-like receptor subfamily B member 2 |
| NCBI Synonym Full Names: | leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 |
| NCBI Official Symbol: | LILRB2 |
| NCBI Official Synonym Symbols: | ILT4; LIR2; CD85D; ILT-4; LIR-2; MIR10; MIR-10 |
| NCBI Protein Information: | leukocyte immunoglobulin-like receptor subfamily B member 2 |
| UniProt Protein Name: | Leukocyte immunoglobulin-like receptor subfamily B member 2 |
| UniProt Synonym Protein Names: | CD85 antigen-like family member D; Immunoglobulin-like transcript 4; ILT-4; Monocyte/macrophage immunoglobulin-like receptor 10; MIR-10; CD_antigen: CD85d |
| UniProt Gene Name: | LILRB2 |
| UniProt Entry Name: | LIRB2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using LILRB2 antibody (CAB12157) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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