Immunology Antibodies 1

Anti-LILRB1 Antibody (CAB12827)

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SKU:
CAB12827
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-LILRB1 Antibody
Antibody SKU:CAB12827
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant protein of human LILRB1
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:Jurkat, Raji, A-431
Immunogen:Recombinant protein of human LILRB1
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:10859
Uniprot:Q8NHL6
Cellular Location:Membrane, Secreted, Single-pass type I membrane protein
Calculated MW:49kDa/70kDa/71kDa
Observed MW:110kDa
Synonyms:LILRB1, CD85J, ILT-2, ILT2, LIR-1, LIR1, MIR-7, MIR7, PIR-B, PIRB
Background:This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.
NCBI Summary:This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q8NHL6
NCBI GenInfo Identifier:37537910
NCBI Gene ID:10859
NCBI Accession:Q8NHL6.1
UniProt Secondary Accession:Q8NHL6,O75024, O75025, Q8NHJ9, Q8NHK0, A2IXV4, A8MXT0
UniProt Related Accession:Q8NHL6
Molecular Weight:49,356 Da
NCBI Full Name:Leukocyte immunoglobulin-like receptor subfamily B member 1
NCBI Synonym Full Names:leukocyte immunoglobulin like receptor B1
NCBI Official Symbol:LILRB1  
NCBI Official Synonym Symbols:ILT2; LIR1; MIR7; PIRB; CD85J; ILT-2; LIR-1; MIR-7; PIR-B  
NCBI Protein Information:leukocyte immunoglobulin-like receptor subfamily B member 1
UniProt Protein Name:Leukocyte immunoglobulin-like receptor subfamily B member 1
UniProt Synonym Protein Names:CD85 antigen-like family member J; Immunoglobulin-like transcript 2; ILT-2; Monocyte/macrophage immunoglobulin-like receptor 7; MIR-7; CD_antigen: CD85j
Protein Family:Leukocyte immunoglobulin-like receptor subfamily
UniProt Gene Name:LILRB1  
UniProt Entry Name:LIRB1_HUMAN
Anti-LILRB1 Antibody (CAB12827)Western blot analysis of extracts of various cell lines, using LILRB1 antibody (CAB12827) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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system_update_altDatasheetHuman LILRB1 Recombinant Protein The immunoglobulin-like transcript (ILT) family (also named leukocyte Ig-like receptors (LIR) and monocyte/macrophage Ig-like receptors