Immunology Antibodies 2

Anti-LILRA2 Antibody (CAB4477)

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SKU:
CAB4477
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
LILRA2
Synonyms:
CD85H
Synonyms:
ILT1
Synonyms:
LIR-7
Synonyms:
LIR7
Research Area:
Immunology

Description

Product Name:LILRA2 Rabbit pAb
Product Code:CAB4477
Size:20uL, 50uL, 100uL
Synonyms:LILRA2, CD85H, ILT1, LIR-7, LIR7
Applications:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 24-240 of human LILRA2 (NP_006857.2).
Applications:WB
Recommended Dilutions:WB 1:200 - 1:2000
Reactivity:Human
Positive Samples:B cells, LO2
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 24-240 of human LILRA2 (NP_006857.2).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:GHLP KPTL WAEP GSVI IQGS PVTL RCQG SLQA EEYH LYRE NKSA SWVR RIQE PGKN GQFP IPSI TWEH AGRY HCQY YSHN HSSE YSDP LELV VTGA YSKP TLSA LPSP VVTS GGNV TLQC VSQV AFDG FILC KEGE DEHP QRLN SHSH ARGW SWAI FSVG PVSP SRRW SYRC YAYD SNSP YVWS LPSD LLEL LVPG VSKK PSLS VQPG PMVA PGES L
Gene ID:11027
Uniprot:Q8N149
Cellular Location:Membrane, Secreted, Single-pass type I membrane protein
Calculated MW:46kDa/48kDa/51kDa/52kDa
Observed MW:53kDa
UniProt Protein Function:LILRA2: Does not bind class I MHC antigens. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 19q13.4

Cellular Component: extracellular region; integral to membrane

Molecular Function:receptor activity; antigen binding

Biological Process: immune system process; defense response; signal transduction

NCBI Summary:This gene encodes a member of a family of immunoreceptors that are expressed predominantly on monocytes and B cells, and at lower levels on dendritic cells and natural killer cells. The encoded protein is an activating receptor that inhibits dendritic cell differentiation and antigen presentation and suppresses innate immune response. Alternatively spliced transcript variants encoding different isoforms have been found. This gene is located in a cluster of related genes on chromosome 19 and there is a pseudogene for this gene on chromosome 3. [provided by RefSeq, Mar 2014]
UniProt Code:Q8N149
NCBI GenInfo Identifier:37537906
NCBI Gene ID:11027
NCBI Accession:Q8N149.2
UniProt Secondary Accession:Q8N149,O75020,
UniProt Related Accession:Q8N149
Molecular Weight:483
NCBI Full Name:Leukocyte immunoglobulin-like receptor subfamily A member 2
NCBI Synonym Full Names:leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2
NCBI Official Symbol:LILRA2  
NCBI Official Synonym Symbols:ILT1; LIR7; CD85H; LIR-7  
NCBI Protein Information:leukocyte immunoglobulin-like receptor subfamily A member 2; immunoglobulin-like transcript 1; CD85 antigen-like family member H; leukocyte immunoglobulin-like receptor 7; leukocyte immunoglobulin-like receptor subfamily A member 2 soluble
UniProt Protein Name:Leukocyte immunoglobulin-like receptor subfamily A member 2
UniProt Synonym Protein Names:CD85 antigen-like family member H; Immunoglobulin-like transcript 1; ILT-1; Leukocyte immunoglobulin-like receptor 7; LIR-7; CD_antigen: CD85h
Protein Family:Leukocyte immunoglobulin-like receptor subfamily
UniProt Gene Name:LILRA2  
UniProt Entry Name:LIRA2_HUMAN
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system_update_altDatasheetHuman LILRA2/ILT1 Recombinant Protein Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 2 (LILRA2) is a single-pass type I membrane protein. LILRA2 is expressed