Immunology Antibodies 1

Anti-LILRA1 Antibody (CAB12111)

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SKU:
CAB12111
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology

Description

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Antibody Name:Anti-LILRA1 Antibody
Antibody SKU:CAB12111
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 17-210 of human LILRA1 (NP_006854.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:B cells, K-562, Mouse brain, Mouse lung, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 17-210 of human LILRA1 (NP_006854.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:PRTH VQAG TLPK PTLW AEPG SVIT QGSP VTLW CQGI LETQ EYRL YREK KTAP WITR IPQE IVKK GQFP IPSI TWEH TGRY RCFY GSHT AGWS EPSD PLEL VVTG AYIK PTLS ALPS PVVT SGGN VTLH CVSQ VAFG SFIL CKEG EDEH PQCL NSQP RTHG WSRA IFSV GPVS PSRR WSYR CYAY DSNS PHVW SL
Gene ID:11024
Uniprot:O75019
Cellular Location:Membrane, Single-pass type I membrane protein
Calculated MW:31kDa/53kDa
Observed MW:53kDa
Synonyms:LILRA1, CD85I, LIR-6, LIR6
Background:This gene encodes an activating member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein is predominantly expressed in B cells, interacts with major histocompatibility complex class I ligands, and contributes to the regulation of immune responses. Alternative splicing results in multiple transcript variants encoding different isoforms.
UniProt Protein Function:LILRA1: May act as receptor for class I MHC antigens. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.4

Cellular Component: integral to membrane; plasma membrane

Molecular Function:transmembrane receptor activity; antigen binding

Biological Process: regulation of immune response; cell surface receptor linked signal transduction; immune system process; defense response

NCBI Summary:This gene encodes an activating member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein is predominantly expressed in B cells, interacts with major histocompatibility complex class I ligands, and contributes to the regulation of immune responses. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]
UniProt Code:O75019
NCBI GenInfo Identifier:37537902
NCBI Gene ID:11024
NCBI Accession:O75019.1
UniProt Secondary Accession:O75019,O75018, Q3MJA6,
UniProt Related Accession:O75019
Molecular Weight:31,724 Da
NCBI Full Name:Leukocyte immunoglobulin-like receptor subfamily A member 1
NCBI Synonym Full Names:leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1
NCBI Official Symbol:LILRA1  
NCBI Official Synonym Symbols:LIR6; CD85I; LIR-6  
NCBI Protein Information:leukocyte immunoglobulin-like receptor subfamily A member 1; CD85 antigen-like family member I; leukocyte immunoglobulin-like receptor 6
UniProt Protein Name:Leukocyte immunoglobulin-like receptor subfamily A member 1
UniProt Synonym Protein Names:CD85 antigen-like family member I; Leukocyte immunoglobulin-like receptor 6; LIR-6; CD_antigen: CD85i
Protein Family:Leukocyte immunoglobulin-like receptor subfamily
UniProt Gene Name:LILRA1  
UniProt Entry Name:LIRA1_HUMAN
Anti-LILRA1 Antibody (CAB12111)Western blot analysis of extracts of various cell lines, using LILRA1 antibody (CAB12111) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.
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