Anti-LI Cadherin/Cadherin-17 Antibody (CAB5286)
- SKU:
- CAB5286
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- CDH16
- Synonyms:
- HPT-1
- Synonyms:
- HPT1
- Research Area:
- Cell Biology
Description
| Product Name: | LI Cadherin/Cadherin-17 Rabbit mAb |
| Product Code: | CAB5286 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | CDH16, HPT-1, HPT1 |
| Applications: | WB, IHC, IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human LI Cadherin/Cadherin-17 |
| Applications: | WB, IHC, IF |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HT-29, Mouse large intestine |
| Immunogen: | A synthesized peptide derived from human LI Cadherin/Cadherin-17 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 1015 |
| Uniprot: | Q12864 |
| Cellular Location: | Cell membrane, Single-pass type I membrane protein |
| Calculated MW: | 120kDa |
| Observed MW: | 120kDa |
| UniProt Protein Function: | CDH17: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 8q22.1 Cellular Component: basolateral plasma membrane; plasma membrane; integral to membrane Molecular Function:transporter activity; calcium ion binding; proton-dependent oligopeptide secondary active transmembrane transporter activity Biological Process: intercellular junction assembly and maintenance; transport; calcium-dependent cell-cell adhesion; cell adhesion; oligopeptide transport; homophilic cell adhesion |
| NCBI Summary: | This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009] |
| UniProt Code: | Q12864 |
| NCBI GenInfo Identifier: | 308153624 |
| NCBI Gene ID: | 1015 |
| NCBI Accession: | Q12864.3 |
| UniProt Secondary Accession: | Q12864,Q15336, Q2M2E0, |
| UniProt Related Accession: | Q12864 |
| Molecular Weight: | 92,219 Da |
| NCBI Full Name: | Cadherin-17 |
| NCBI Synonym Full Names: | cadherin 17, LI cadherin (liver-intestine) |
| NCBI Official Symbol: | CDH17 |
| NCBI Official Synonym Symbols: | HPT1; CDH16; HPT-1 |
| NCBI Protein Information: | cadherin-17; LI cadherin; LI-cadherin; cadherin-16; HPT-1 cadherin; liver-intestine cadherin; human peptide transporter 1; intestinal peptide-associated transporter HPT-1; human intestinal peptide-associated transporter HPT-1 |
| UniProt Protein Name: | Cadherin-17 |
| UniProt Synonym Protein Names: | Intestinal peptide-associated transporter HPT-1; Liver-intestine cadherin; LI-cadherin |
| Protein Family: | Cadherin |
| UniProt Gene Name: | CDH17 |
| UniProt Entry Name: | CAD17_HUMAN |
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