Epigenetics & Nuclear Signaling Antibodies 3
Anti-LHX8 Antibody (CAB2046)
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- SKU:
- CAB2046
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-LHX8 Antibody |
| Antibody SKU: | CAB2046 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human LHX8 (NP_001001933.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse brain, Mouse testis, Mouse ovary, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human LHX8 (NP_001001933.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MQIL SRCQ GLMS EECG RTTA LAAG RTRK GAGE EGLV SPEG AGDE DSCS SSAP LSPS SSPR SMAS GSGC PPGK CVCN SCGL EIVD KYLL KVND LCWH VRCL SCSV CRTS LGRH TSCY IKDK DIFC KLDY FRRY GTRC SRCG RHIH STDW VRRA KGNV YHLA CFAC FSCK RQLS TGEE FALV EEKV LCRV HYDC MLDN LKRE VENG NGIS VEGA LLTE QDVN |
| Gene ID: | 431707 |
| Uniprot: | Q68G74 |
| Cellular Location: | Nucleus |
| Calculated MW: | 38kDa/39kDa |
| Observed MW: | 39kDa |
| Synonyms: | LHX8, LHX7 |
| Background: | The protein encoded by this gene is a member of the LIM homeobox family of proteins, which are involved in patterning and differentiation of various tissue types. These proteins contain two tandemly repeated cysteine-rich double-zinc finger motifs known as LIM domains, in addition to a DNA-binding homeodomain. This family member is a transcription factor that plays a role in tooth morphogenesis. It is also involved in oogenesis and in neuronal differentiation. This gene is a candidate gene for cleft palate, and it is also associated with odontoma formation. Alternative splicing of this gene results in multiple transcript variants. |
| UniProt Protein Function: | LHX8: Transcription factor involved in differentiation of certain neurons and mesenchymal cells. |
| UniProt Protein Details: | Protein type:DNA-binding; Transcription factor; Cell development/differentiation Chromosomal Location of Human Ortholog: 1p31.1 Cellular Component: female germ cell nucleus Molecular Function:zinc ion binding; sequence-specific DNA binding Biological Process: learning and/or memory; regulation of transcription, DNA-dependent; transcription, DNA-dependent; forebrain neuron development; female gonad development; odontogenesis of dentine-containing teeth |
| NCBI Summary: | The protein encoded by this gene is a member of the LIM homeobox family of proteins, which are involved in patterning and differentiation of various tissue types. These proteins contain two tandemly repeated cysteine-rich double-zinc finger motifs known as LIM domains, in addition to a DNA-binding homeodomain. This family member is a transcription factor that plays a role in tooth morphogenesis. It is also involved in oogenesis and in neuronal differentiation. This gene is a candidate gene for cleft palate, and it is also associated with odontoma formation. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012] |
| UniProt Code: | Q68G74 |
| NCBI GenInfo Identifier: | 296434566 |
| NCBI Gene ID: | 431707 |
| NCBI Accession: | Q68G74.2 |
| UniProt Related Accession: | Q68G74 |
| Molecular Weight: | |
| NCBI Full Name: | LIM/homeobox protein Lhx8 |
| NCBI Synonym Full Names: | LIM homeobox 8 |
| NCBI Official Symbol: | LHX8 |
| NCBI Official Synonym Symbols: | LHX7 |
| NCBI Protein Information: | LIM/homeobox protein Lhx8 |
| UniProt Protein Name: | LIM/homeobox protein Lhx8 |
| Protein Family: | LIM/homeobox protein |
| UniProt Gene Name: | LHX8 |
| UniProt Entry Name: | LHX8_HUMAN |
 | Western blot analysis of extracts of various cell lines, using LHX8 antibody (CAB2046) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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