Developmental Biology
Anti-LHX6 Antibody (CAB7364)
- SKU:
- CAB7364
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Description
| Antibody Name: | Anti-LHX6 Antibody |
| Antibody SKU: | CAB7364 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 143-392 of human LHX6 (NP_055183.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SW480, U-87MG, HepG2, NIH/3T3, Mouse brain, Mouse liver, Mouse heart, Rat brain, Rat heart |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 143-392 of human LHX6 (NP_055183.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | NKEI FCKM DYFS RFGT KCAR CGRQ IYAS DWVR RARG NAYH LACF ACFS CKRQ LSTG EEFG LVEE KVLC RIHY DTMI ENLK RAAE NGNG LTLE GAVP SEQD SQPK PAKR ARTS FTAE QLQV MQAQ FAQD NNPD AQTL QKLA DMTG LSRR VIQV WFQN CRAR HKKH TPQH PVPP SGAP PSRL PSAL SDDI HYTP FSSP ERAR MVTL HGYI ESQV QCGQ VHCR LPYT APPV HLKA DMDG PLSN RGEK VILF QY |
| Gene ID: | 26468 |
| Uniprot: | Q9UPM6 |
| Cellular Location: | Nucleus |
| Calculated MW: | 19kDa/38kDa/40kDa/41kDa/43kDa |
| Observed MW: | 45kDa |
| Synonyms: | LHX6, LHX6.1 |
| Background: | This gene encodes a member of a large protein family that contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein has tandem LIM domains as well as a DNA-binding homeodomain. The protein functions as a transcription factor involved in embryogenesis and head development and is highly expressed in neural crest derived mesenchyme cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
| UniProt Protein Function: | LHX6: Probable transcription factor required for the expression of a subset of genes involved in interneurons migration and development. Functions in the specification of cortical interneuron subtypes and in the migration of GABAergic interneuron precursors from the subpallium to the cerebral cortex. 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 9q33.2 Cellular Component: nucleus Molecular Function:protein binding Biological Process: cell maturation; cerebral cortex GABAergic interneuron migration; cerebral cortex radially oriented cell migration; cerebral cortex tangential migration |
| NCBI Summary: | This gene encodes a member of a large protein family that contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator and may be involved in the control of differentiation and development of neural and lymphoid cells. Two alternatively spliced transcript variants encoding distinct isoforms have been described for this gene. Alternatively spliced transcript variants have been identified, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UPM6 |
| NCBI GenInfo Identifier: | 90185239 |
| NCBI Gene ID: | 26468 |
| NCBI Accession: | Q9UPM6.2 |
| UniProt Secondary Accession: | Q9UPM6,Q5T7S7, Q5T7S8, Q9NTK3, Q9UPM5, A6PVQ1, A6PVQ2 A8K1B2, B7Z4D0, H0YN76, |
| UniProt Related Accession: | Q9UPM6 |
| Molecular Weight: | 19,618 Da |
| NCBI Full Name: | LIM/homeobox protein Lhx6 |
| NCBI Synonym Full Names: | LIM homeobox 6 |
| NCBI Official Symbol: | LHX6 |
| NCBI Official Synonym Symbols: | LHX6.1 |
| NCBI Protein Information: | LIM/homeobox protein Lhx6 |
| UniProt Protein Name: | LIM/homeobox protein Lhx6 |
| UniProt Synonym Protein Names: | LIM/homeobox protein Lhx6.1 |
| Protein Family: | LIM/homeobox protein |
| UniProt Gene Name: | LHX6 |
| UniProt Entry Name: | LHX6_HUMAN |
 | Western blot analysis of extracts of various cell lines, using LHX6 antibody (CAB7364) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 90s. |
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