Epigenetics & Nuclear Signaling Antibodies 4
Anti-LHX4 Antibody (CAB8072)
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- SKU:
- CAB8072
- Product Type:
- Antibody
- Applications:
- WB
- Applications:
- IHC
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | LHX4 Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB8072 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 121-390 of human LHX4 (NP_203129.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse brain, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 121-390 of human LHX4 (NP_203129.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | NRQL ATGD EFYL MEDG RLVC KEDY ETAK QNDD SEAG AKRP RTTI TAKQ LETL KNAY KNSP KPAR HVRE QLSS ETGL DMRV VQVW FQNR RAKE KRLK KDAG RHRW GQFY KSVK RSRG SSKQ EKES SAED CGVS DSEL SFRE DQIL SELG HTNR IYGN VGDV TGGQ LMNG SFSM DGTG QSYQ DLRD GSPY GIPQ SPSS ISSL PSHA PLLN GLDY TVDS NLGI IAHA GQGV SQTL RAMA GGPT SDIS TGSS VGYP DFPT SPGS WLDE MDHP PF |
| Gene ID: | 89884 |
| Uniprot: | Q969G2 |
| Cellular Location: | Nucleus |
| Calculated MW: | 43kDa |
| Observed MW: | 43kDa |
| Synonyms: | LHX4, CPHD4 |
| Background: | This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor involved in the control of differentiation and development of the pituitary gland. Mutations in this gene cause combined pituitary hormone deficiency 4. |
| UniProt Protein Function: | LHX4: May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung. Defects in LHX4 are the cause of pituitary hormone deficiency combined type 4 (CPHD4); also known as short stature pituitary and cerebellar defects and small sella turcica. The disorder is characterized by short stature, pituitary and cerebellar defects, and small transverse depression crossing the midline on the superior surface of the body of the sphenoid bone which houses the pituitary gland. A chromosomal aberration involving LHX4 may be a cause of acute lymphoblastic leukemia. Translocation t(1;14)(q25;q32) with IGHG1. |
| UniProt Protein Details: | Protein type:Oncoprotein; DNA-binding Chromosomal Location of Human Ortholog: 1q25.2 Molecular Function:protein binding Disease: Pituitary Hormone Deficiency, Combined, 4 |
| NCBI Summary: | This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor involved in the control of differentiation and development of the pituitary gland. Mutations in this gene cause combined pituitary hormone deficiency 4. [provided by RefSeq, Dec 2010] |
| UniProt Code: | Q969G2 |
| NCBI GenInfo Identifier: | 209572644 |
| NCBI Gene ID: | 89884 |
| NCBI Accession: | Q969G2.2 |
| UniProt Secondary Accession: | Q969G2,Q8NHE0, Q8NHM1, Q8TCJ1, Q8WWX2, Q969W2, |
| UniProt Related Accession: | Q969G2 |
| Molecular Weight: | 43,124 Da |
| NCBI Full Name: | LIM/homeobox protein Lhx4 |
| NCBI Synonym Full Names: | LIM homeobox 4 |
| NCBI Official Symbol: | LHX4 |
| NCBI Official Synonym Symbols: | CPHD4 |
| NCBI Protein Information: | LIM/homeobox protein Lhx4 |
| UniProt Protein Name: | LIM/homeobox protein Lhx4 |
| Protein Family: | LIM/homeobox protein |
| UniProt Gene Name: | LHX4 |
| UniProt Entry Name: | LHX4_HUMAN |
 | Western blot analysis of extracts of various cell lines, using LHX4 Antibody (CAB8072) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded human kidney cancer using LHX4 antibody (CAB8072) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse cancer using LHX4 antibody (CAB8072) at dilution of 1:100 (40x lens). |
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