Signal Transduction Antibodies 1

Anti-LHPP Antibody (CAB14342)

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SKU:
CAB14342
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-LHPP Antibody
Antibody SKU:CAB14342
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human LHPP (NP_071409.3).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse brain, Mouse liver, Rat liver, Rat kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human LHPP (NP_071409.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAPW GKRL AGVR GVLL DISG VLYD SGAG GGTA IAGS VEAV ARLK RSRL KVRF CTNE SQKS RAEL VGQL QRLG FDIS EQEV TAPA PAAC QILK EQGL RPYL LIHD GVRS EFDQ IDTS NPNC VVIA DAGE SFSY QNMN NAFQ VLME LEKP VLIS LGKG RYYK ETSG LMLD VGPY MKAL EYAC GIKA EVVG KPSP EFFK SALQ AIGV EAHQ AVMI GDDI VGDV GGAQ RCGM RALQ VRTG KFRP SDEH HPEV KADG YVDN LAEA VDLL LQHA DK
Gene ID:64077
Uniprot:Q9H008
Cellular Location:Cytoplasm, Nucleus
Calculated MW:22kDa/29kDa
Observed MW:29kDa
Synonyms:LHPP, HDHD2B
Background:
UniProt Protein Function:LHPP: Phosphatase that hydrolyzes imidodiphosphate, 3- phosphohistidine and 6-phospholysine. Has broad substrate specificity and can also hydrolyze inorganic diphosphate, but with lower efficiency. Belongs to the HAD-like hydrolase superfamily. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Hydrolase; Mitochondrial; EC 3.6.1.1; Energy Metabolism - oxidative phosphorylation

Chromosomal Location of Human Ortholog: 10q26.13

Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus

Molecular Function:inorganic diphosphatase activity; magnesium ion binding; phosphohistidine phosphatase activity; protein homodimerization activity

Biological Process: phosphate metabolic process; protein amino acid dephosphorylation; purine ribonucleoside monophosphate biosynthetic process

UniProt Code:Q9H008
NCBI GenInfo Identifier:158705883
NCBI Gene ID:64077
NCBI Accession:Q9H008.2
UniProt Secondary Accession:Q9H008,Q2TBE9, Q5VUV9, Q5VUW0, B3KP20,
UniProt Related Accession:Q9H008
Molecular Weight:22,696 Da
NCBI Full Name:Phospholysine phosphohistidine inorganic pyrophosphate phosphatase
NCBI Synonym Full Names:phospholysine phosphohistidine inorganic pyrophosphate phosphatase
NCBI Official Symbol:LHPP  
NCBI Official Synonym Symbols:HDHD2B  
NCBI Protein Information:phospholysine phosphohistidine inorganic pyrophosphate phosphatase
UniProt Protein Name:Phospholysine phosphohistidine inorganic pyrophosphate phosphatase
Protein Family:Phospholysine phosphohistidine inorganic pyrophosphate phosphatase
UniProt Gene Name:LHPP  
UniProt Entry Name:LHPP_HUMAN
Anti-LHPP Antibody (CAB14342)Western blot analysis of extracts of various cell lines, using LHPP antibody (CAB14342) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3s.
Anti-LHPP Antibody (CAB14342)Immunofluorescence analysis of L929 cells using LHPP antibody (CAB14342) at dilution of 1:100. Blue: DAPI for nuclear staining.
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