Name: Anti-LGR6 Antibody (CAB14173)
Brand: Metabolism Antibodies 1
SKU: CAB14173
Availability: OutOfStock

Antibody Name:	Anti-LGR6 Antibody
Antibody SKU:	CAB14173
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Rat
Host Species:	Rabbit
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 700-800 of human LGR6 (NP_001017404.1).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human, Rat
Positive Samples:	Rat testis

Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 700-800 of human LGR6 (NP_001017404.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	RRLR PRAG DSGP LAYA AAGE LEKS SCDS TQAL VAFS DVDL ILEA SEAG RPPG LETY GFPS VTLI SCQQ PGAP RLEG SHCV EPEG NHFG NPQP SMDG ELLL R
Gene ID:	59352
Uniprot:	Q9HBX8
Cellular Location:	Cell membrane, Multi-pass membrane protein
Calculated MW:	89kDa/99kDa/104kDa
Observed MW:	98kDa

Synonyms:

LGR6, GPCR, VTS20631

Background:

This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane protein superfamily. The encoded protein is a glycoprotein hormone receptor with a large N-terminal extracellular domain that contains leucine-rich repeats important for the formation of a horseshoe-shaped interaction motif for ligand binding. Alternative splicing of this gene results in multiple transcript variants.

UniProt Protein Function:	LGR6: a leucine-rich repeat-containing G-protein-coupled receptor. Receptor for R-spondins, potent stimulators of adult stem cell proliferation. A marker of adult stem cells. A Wnt receptor component that enhances Wnt signaling by soluble R-spondin proteins. A marker of a multipotent population of skin stem cells. Three isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR; Tumor suppressor; Membrane protein, integral Chromosomal Location of Human Ortholog: 1q32.1 Cellular Component: integral to plasma membrane; plasma membrane; trans-Golgi network membrane; vesicle Molecular Function:G-protein coupled receptor activity; protein binding; transmembrane receptor activity Biological Process: G-protein coupled receptor protein signaling pathway; positive regulation of cell migration; positive regulation of Wnt receptor signaling pathway; Wnt receptor signaling pathway
NCBI Summary:	This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane protein superfamily. The encoded protein is a glycoprotein hormone receptor with a large N-terminal extracellular domain that contains leucine-rich repeats important for the formation of a horseshoe-shaped interaction motif for ligand binding. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
UniProt Code:	Q9HBX8
NCBI GenInfo Identifier:	158519993
NCBI Gene ID:	59352
NCBI Accession:	Q9HBX8.3
UniProt Secondary Accession:	Q9HBX8,Q5T509, Q5T512, Q6UY15, Q86VU0, Q96K69, Q9BYD7
UniProt Related Accession:	Q9HBX8
Molecular Weight:	99,295 Da
NCBI Full Name:	Leucine-rich repeat-containing G-protein coupled receptor 6
NCBI Synonym Full Names:	leucine-rich repeat containing G protein-coupled receptor 6
NCBI Official Symbol:	LGR6
NCBI Official Synonym Symbols:	GPCR; VTS20631
NCBI Protein Information:	leucine-rich repeat-containing G-protein coupled receptor 6
UniProt Protein Name:	Leucine-rich repeat-containing G-protein coupled receptor 6
Protein Family:	Leucine-rich repeat-containing G-protein coupled receptor
UniProt Gene Name:	LGR6
UniProt Entry Name:	LGR6_HUMAN

Western blot analysis of extracts of rat testis, using LGR6 antibody (CAB14173) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.

Antibodies

Anti-LGR6 Antibody (CAB7383)

Anti-GPCR / LGR6 Antibody (CAB9128)

LGR6 Antibody (PACO01021)

LGR6 Antibody (PACO10243)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)