Metabolism Antibodies 1
Anti-LGR6 Antibody (CAB14173)
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- SKU:
- CAB14173
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-LGR6 Antibody |
| Antibody SKU: | CAB14173 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 700-800 of human LGR6 (NP_001017404.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Rat |
| Positive Samples: | Rat testis |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 700-800 of human LGR6 (NP_001017404.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | RRLR PRAG DSGP LAYA AAGE LEKS SCDS TQAL VAFS DVDL ILEA SEAG RPPG LETY GFPS VTLI SCQQ PGAP RLEG SHCV EPEG NHFG NPQP SMDG ELLL R |
| Gene ID: | 59352 |
| Uniprot: | Q9HBX8 |
| Cellular Location: | Cell membrane, Multi-pass membrane protein |
| Calculated MW: | 89kDa/99kDa/104kDa |
| Observed MW: | 98kDa |
| Synonyms: | LGR6, GPCR, VTS20631 |
| Background: | This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane protein superfamily. The encoded protein is a glycoprotein hormone receptor with a large N-terminal extracellular domain that contains leucine-rich repeats important for the formation of a horseshoe-shaped interaction motif for ligand binding. Alternative splicing of this gene results in multiple transcript variants. |
| UniProt Protein Function: | LGR6: a leucine-rich repeat-containing G-protein-coupled receptor. Receptor for R-spondins, potent stimulators of adult stem cell proliferation. A marker of adult stem cells. A Wnt receptor component that enhances Wnt signaling by soluble R-spondin proteins. A marker of a multipotent population of skin stem cells. Three isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR; Tumor suppressor; Membrane protein, integral Chromosomal Location of Human Ortholog: 1q32.1 Cellular Component: integral to plasma membrane; plasma membrane; trans-Golgi network membrane; vesicle Molecular Function:G-protein coupled receptor activity; protein binding; transmembrane receptor activity Biological Process: G-protein coupled receptor protein signaling pathway; positive regulation of cell migration; positive regulation of Wnt receptor signaling pathway; Wnt receptor signaling pathway |
| NCBI Summary: | This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane protein superfamily. The encoded protein is a glycoprotein hormone receptor with a large N-terminal extracellular domain that contains leucine-rich repeats important for the formation of a horseshoe-shaped interaction motif for ligand binding. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9HBX8 |
| NCBI GenInfo Identifier: | 158519993 |
| NCBI Gene ID: | 59352 |
| NCBI Accession: | Q9HBX8.3 |
| UniProt Secondary Accession: | Q9HBX8,Q5T509, Q5T512, Q6UY15, Q86VU0, Q96K69, Q9BYD7 |
| UniProt Related Accession: | Q9HBX8 |
| Molecular Weight: | 99,295 Da |
| NCBI Full Name: | Leucine-rich repeat-containing G-protein coupled receptor 6 |
| NCBI Synonym Full Names: | leucine-rich repeat containing G protein-coupled receptor 6 |
| NCBI Official Symbol: | LGR6 |
| NCBI Official Synonym Symbols: | GPCR; VTS20631 |
| NCBI Protein Information: | leucine-rich repeat-containing G-protein coupled receptor 6 |
| UniProt Protein Name: | Leucine-rich repeat-containing G-protein coupled receptor 6 |
| Protein Family: | Leucine-rich repeat-containing G-protein coupled receptor |
| UniProt Gene Name: | LGR6 |
| UniProt Entry Name: | LGR6_HUMAN |
 | Western blot analysis of extracts of rat testis, using LGR6 antibody (CAB14173) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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