Cell Biology Antibodies 3

Anti-LGR4 Antibody (CAB12658)

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SKU:
CAB12658
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-LGR4 Antibody
Antibody SKU:CAB12658
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 320-540 of human LGR4 (NP_060960.2).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human
Positive Samples:SGC-7901, 293T, LO2
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 320-540 of human LGR4 (NP_060960.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:HLES LTLT GTKI SSIP NNLC QEQK MLRT LDLS YNNI RDLP SFNG CHAL EEIS LQRN QIYQ IKEG TFQG LISL RILD LSRN LIHE IHSR AFAT LGPI TNLD VSFN ELTS FPTE GLNG LNQL KLVG NFKL KEAL AAKD FVNL RSLS VPYA YQCC AFWG CDSY ANLN TEDN SLQD HSVA QEKG TADA ANVT STLE NEEH SQII IHCT PSTG AFKP CEYL LGSW M
Gene ID:55366
Uniprot:Q9BXB1
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:101kDa/104kDa
Observed MW:104kDa
Synonyms:LGR4, BNMD17, GPR48
Background:
UniProt Protein Function:LGR4: a leucine-rich repeat-containing G-protein-coupled receptor. Receptor for R-spondins, potent stimulators of adult stem cell proliferation. A Wnt receptor component that enhances Wnt signaling by soluble R-spondin proteins. Plays an essential role during homeostasis of the adult mouse intestine.
UniProt Protein Details:

Protein type:GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 11p14.1

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function:G-protein coupled receptor activity; protein binding; transmembrane receptor activity

Biological Process: bone mineralization; bone remodeling; circadian regulation of gene expression; negative regulation of cytokine secretion; negative regulation of toll-like receptor signaling pathway; osteoblast differentiation; spermatogenesis

Disease: Bone Mineral Density Quantitative Trait Locus 17

NCBI Summary:The protein encoded by this gene is a G-protein coupled receptor that binds R-spondins and activates the Wnt signaling pathway. This Wnt signaling pathway activation is necessary for proper development of many organs of the body. [provided by RefSeq, Oct 2016]
UniProt Code:Q9BXB1
NCBI GenInfo Identifier:212286375
NCBI Gene ID:55366
NCBI Accession:Q9BXB1.2
UniProt Secondary Accession:Q9BXB1,Q8N537, Q9NYD1, A6NCH3, G5E9B3,
UniProt Related Accession:Q9BXB1
Molecular Weight:104kDa
NCBI Full Name:Leucine-rich repeat-containing G-protein coupled receptor 4
NCBI Synonym Full Names:leucine rich repeat containing G protein-coupled receptor 4
NCBI Official Symbol:LGR4  
NCBI Official Synonym Symbols:GPR48; BNMD17  
NCBI Protein Information:leucine-rich repeat-containing G-protein coupled receptor 4
UniProt Protein Name:Leucine-rich repeat-containing G-protein coupled receptor 4
UniProt Synonym Protein Names:G-protein coupled receptor 48
Protein Family:Leucine-rich repeat-containing G-protein coupled receptor
UniProt Gene Name:LGR4  
Anti-LGR4 Antibody (CAB12658)Western blot analysis of extracts of various cell lines, using LGR4 antibody (CAB12658) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 120s.
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