Cell Biology Antibodies 10

Anti-LGALS3BP Antibody (CAB6929)

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SKU:
CAB6929
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-LGALS3BP Antibody
Antibody SKU:CAB6929
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 306-585 of human LGALS3BP (NP_005558.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:HepG2, HT-29, 293T, HeLa, Mouse liver, Mouse kidney, Mouse lung, Rat brain, Rat lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 306-585 of human LGALS3BP (NP_005558.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LLLP RSDL AVPS ELAL LKAV DTWS WGER ASHE EVEG LVEK IRFP MMLP EELF ELQF NLSL YWSH EALF QKKT LQAL EFHT VPFQ LLAR YKGL NLTE DTYK PRIY TSPT WSAF VTDS SWSA RKSQ LVYQ SRRG PLVK YSSD YFQA PSDY RYYP YQSF QTPQ HPSF LFQD KRVS WSLV YLPT IQSC WNYG FSCS SDEL PVLG LTKS GGSD RTIA YENK ALML CEGL FVAD VTDF EGWK AAIP SALD TNSS KSTS SFPC PAGH FNGF RTVI RPFY LTNS SGVD
Gene ID:3959
Uniprot:Q08380
Cellular Location:Secreted, extracellular matrix, extracellular space
Calculated MW:65kDa
Observed MW:75kDa-110kDa
Synonyms:LGALS3BP, 90K, BTBD17B, CyCAP, M2BP, MAC-2-BP, TANGO10B, gp90
Background:The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS3BP has been found elevated in the serum of patients with cancer and in those infected by the human immunodeficiency virus (HIV). It appears to be implicated in immune response associated with natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxicity. Using fluorescence in situ hybridization the full length 90K cDNA has been localized to chromosome 17q25. The native protein binds specifically to a human macrophage-associated lectin known as Mac-2 and also binds galectin 1.
UniProt Protein Function:LGALS3BP: Promotes intergrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 17q25.3

Cellular Component: extracellular matrix; extracellular region; extracellular space

Biological Process: cellular defense response; platelet degranulation; signal transduction

NCBI Summary:The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS3BP has been found elevated in the serum of patients with cancer and in those infected by the human immunodeficiency virus (HIV). It appears to be implicated in immune response associated with natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxicity. Using fluorescence in situ hybridization the full length 90K cDNA has been localized to chromosome 17q25. The native protein binds specifically to a human macrophage-associated lectin known as Mac-2 and also binds galectin 1. [provided by RefSeq, Jul 2008]
UniProt Code:Q08380
NCBI GenInfo Identifier:47115668
NCBI Gene ID:3959
NCBI Accession:Q08380.1
UniProt Secondary Accession:Q08380,Q7M4S0, Q9UCH8, Q9UCH9, Q9UCI0,
UniProt Related Accession:Q08380
Molecular Weight:65kDa
NCBI Full Name:Galectin-3-binding protein
NCBI Synonym Full Names:galectin 3 binding protein
NCBI Official Symbol:LGALS3BP  
NCBI Official Synonym Symbols:90K; M2BP; gp90; CyCAP; BTBD17B; MAC-2-BP; TANGO10B  
NCBI Protein Information:galectin-3-binding protein
UniProt Protein Name:Galectin-3-binding protein
UniProt Synonym Protein Names:Basement membrane autoantigen p105; Lectin galactoside-binding soluble 3-binding protein; Mac-2-binding protein; MAC2BP; Mac-2 BP; Tumor-associated antigen 90K
Protein Family:Galectin-3-binding protein
UniProt Gene Name:LGALS3BP  
Anti-LGALS3BP Antibody (CAB6929)Western blot analysis of extracts of various cell lines, using LGALS3BP antibody (CAB6929) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-LGALS3BP Antibody (CAB6929)Immunofluorescence analysis of MCF7 cells using LGALS3BP antibody (CAB6929). Blue: DAPI for nuclear staining.
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