Cell Biology Antibodies 2
Anti-LGALS3BP Antibody (CAB12005)
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- SKU:
- CAB12005
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-LGALS3BP Antibody |
| Antibody SKU: | CAB12005 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 6-221 of human LGALS3BP (NP_005558.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | A-549, HeLa, Mouse liver, Mouse kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 6-221 of human LGALS3BP (NP_005558.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LFWV WLLV AGTQ GVND GDMR LADG GATN QGRV EIFY RGQW GTVC DNLW DLTD ASVV CRAL GFEN ATQA LGRA AFGQ GSGP IMLD EVQC TGTE ASLA DCKS LGWL KSNC RHER DAGV VCTN ETRS THTL DLSR ELSE ALGQ IFDS QRGC DLSI SVNV QGED ALGF CGHT VILT ANLE AQAL WKEP GSNV TMSV DAEC VPMV RDLL RYFY SRRI DITL |
| Gene ID: | 3959 |
| Uniprot: | Q08380 |
| Cellular Location: | Secreted, extracellular matrix, extracellular space |
| Calculated MW: | 65kDa |
| Observed MW: | 70kDa |
| Synonyms: | LGALS3BP, 90K, BTBD17B, CyCAP, M2BP, MAC-2-BP, TANGO10B, gp90 |
| Background: | The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS3BP has been found elevated in the serum of patients with cancer and in those infected by the human immunodeficiency virus (HIV). It appears to be implicated in immune response associated with natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxicity. Using fluorescence in situ hybridization the full length 90K cDNA has been localized to chromosome 17q25. The native protein binds specifically to a human macrophage-associated lectin known as Mac-2 and also binds galectin 1. |
| UniProt Protein Function: | LGALS3BP: Promotes intergrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 17q25.3 Cellular Component: extracellular matrix; extracellular region; extracellular space Biological Process: cellular defense response; platelet degranulation; signal transduction |
| NCBI Summary: | The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS3BP has been found elevated in the serum of patients with cancer and in those infected by the human immunodeficiency virus (HIV). It appears to be implicated in immune response associated with natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxicity. Using fluorescence in situ hybridization the full length 90K cDNA has been localized to chromosome 17q25. The native protein binds specifically to a human macrophage-associated lectin known as Mac-2 and also binds galectin 1. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q08380 |
| NCBI GenInfo Identifier: | 47115668 |
| NCBI Gene ID: | 3959 |
| NCBI Accession: | Q08380.1 |
| UniProt Secondary Accession: | Q08380,Q7M4S0, Q9UCH8, Q9UCH9, Q9UCI0, |
| UniProt Related Accession: | Q08380 |
| Molecular Weight: | 65kDa |
| NCBI Full Name: | Galectin-3-binding protein |
| NCBI Synonym Full Names: | galectin 3 binding protein |
| NCBI Official Symbol: | LGALS3BP |
| NCBI Official Synonym Symbols: | 90K; M2BP; gp90; CyCAP; BTBD17B; MAC-2-BP; TANGO10B |
| NCBI Protein Information: | galectin-3-binding protein |
| UniProt Protein Name: | Galectin-3-binding protein |
| UniProt Synonym Protein Names: | Basement membrane autoantigen p105; Lectin galactoside-binding soluble 3-binding protein; Mac-2-binding protein; MAC2BP; Mac-2 BP; Tumor-associated antigen 90K |
| Protein Family: | Galectin-3-binding protein |
| UniProt Gene Name: | LGALS3BP |
 | Western blot analysis of extracts of various cell lines, using LGALS3BP antibody (CAB12005) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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