Cell Biology Antibodies 12

Anti-Leupaxin Antibody (CAB9803)

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SKU:
CAB9803
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-Leupaxin Antibody
Antibody SKU:CAB9803
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human LPXN (NP_004802.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:Jurkat, Mouse spleen, Rat testis
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human LPXN (NP_004802.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MEEL DALL EELE RSTL QDSD EYSN PAPL PLDQ HSRK ETNL DETS EILS IQDN TSPL PAQL VYTT NIQE LNVY SEAQ EPKE SPPP SKTS AAAQ LDEL MAHL TEMQ AKVA VRAD AGKK HLPD KQDH KASL DSML GGLE QELQ DLGI ATVP KG
Gene ID:9404
Uniprot:O60711
Cellular Location:Cell junction, Cell membrane, Cell projection, Cytoplasm, Nucleus, focal adhesion, perinuclear region, podosome
Calculated MW:43kDa
Observed MW:43kDa
Synonyms:LPXN, LDPL, leupaxin
Background:The product encoded by this gene is preferentially expressed in hematopoietic cells and belongs to the paxillin protein family. Similar to other members of this focal-adhesion-associated adaptor-protein family, it has four leucine-rich LD-motifs in the N-terminus and four LIM domains in the C-terminus. It may function in cell type-specific signaling by associating with PYK2, a member of focal adhesion kinase family. As a substrate for a tyrosine kinase in lymphoid cells, this protein may also function in, and be regulated by, tyrosine kinase activity. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
UniProt Protein Function:leupaxin: a LIM domain-containing cytoplasmic protein preferentially expressed in hematopoietic cells. Homologous to the focal adhesion protein, paxillin. Associates with PYK2, a member of focal adhesion kinase family, it may participate in signaling at sites of adhesion..
UniProt Protein Details:

Protein type:Adaptor/scaffold; Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 11q12.1

Cellular Component: cell projection; focal adhesion; membrane; perinuclear region of cytoplasm; cytoplasm; plasma membrane; podosome; nucleus

Molecular Function:protein binding; zinc ion binding; transcription cofactor activity

Biological Process: regulation of cell adhesion mediated by integrin; transcription, DNA-dependent; regulation of transcription, DNA-dependent; negative regulation of B cell receptor signaling pathway; protein complex assembly; negative regulation of cell adhesion; signal transduction; cell adhesion

NCBI Summary:The product encoded by this gene is preferentially expressed in hematopoietic cells and belongs to the paxillin protein family. Similar to other members of this focal-adhesion-associated adaptor-protein family, it has four leucine-rich LD-motifs in the N-terminus and four LIM domains in the C-terminus. It may function in cell type-specific signaling by associating with PYK2, a member of focal adhesion kinase family. As a substrate for a tyrosine kinase in lymphoid cells, this protein may also function in, and be regulated by, tyrosine kinase activity. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]
UniProt Code:O60711
NCBI GenInfo Identifier:8134557
NCBI Gene ID:9404
NCBI Accession:O60711.1
UniProt Secondary Accession:O60711,Q53FW6, Q6FI07, B2R8B4, B4DV71,
UniProt Related Accession:O60711
Molecular Weight:43,750 Da
NCBI Full Name:Leupaxin
NCBI Synonym Full Names:leupaxin
NCBI Official Symbol:LPXN  
NCBI Official Synonym Symbols:LDPL  
NCBI Protein Information:leupaxin
UniProt Protein Name:Leupaxin
Protein Family:Leupaxin
UniProt Gene Name:LPXN  
UniProt Entry Name:LPXN_HUMAN
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