Cell Biology Antibodies 8

Anti-LEPREL2 Antibody (CAB2293)

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SKU:
CAB2293
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-LEPREL2 Antibody
Antibody SKU:CAB2293
Antibody Size:20uL, 50uL, 100uL
Application:IHC
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 487-736 of human LEPREL2 (NP_055077.2).
Application:IHC
Recommended Dilution:IHC 1:50 - 1:200
Reactivity:Mouse, Rat
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 487-736 of human LEPREL2 (NP_055077.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:DAAG AGAR SGYR GRRS PHTP HERF EGLT VLKA AQLA RAGT VGSQ GAKL LLEV SERV RTLT QAYF SPER PLHL SFTH LVCR SAIE GEQE QRMD LSHP VHAD NCVL DPDT GECW REPP AYTY RDYS GLLY LNDD FQGG DLFF TEPN ALTV TARV RPRC GRLV AFSS GVEN PHGV WAVT RGRR CALA LWHT WAPE HREQ EWIE AKEL LQES QEEE EEEE EEMP SKDP SPEP PSRR HQRV QDKT GRAP RVRE EL
Gene ID:10536
Uniprot:Q8IVL6
Cellular Location:Endoplasmic reticulum
Calculated MW:62kDa/81kDa
Observed MW:
Synonyms:P3H3, GRCB, HSU47926, LEPREL2
Background:The protein encoded by this gene belongs to the leprecan family of proteoglycans, which function as collagen prolyl hydroxylases that are required for proper collagen biosynthesis, folding and assembly. This protein, like other family members, is thought to reside in the endoplasmic reticulum. Epigenetic inactivation of this gene is associated with breast and other cancers, suggesting that it may function as a tumor suppressor.
UniProt Protein Function:LEPREL2: Has prolyl 3-hydroxylase activity catalyzing the post- translational formation of 3-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens, especially types IV and V. Belongs to the leprecan family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 1.14.11.7; Oxidoreductase

Chromosomal Location of Human Ortholog: 12p13.31

Cellular Component: endoplasmic reticulum lumen

Molecular Function:procollagen-proline 3-dioxygenase activity; L-ascorbic acid binding; iron ion binding

Biological Process: negative regulation of cell proliferation; extracellular matrix organization and biogenesis; peptidyl-proline hydroxylation

NCBI Summary:The protein encoded by this gene belongs to the leprecan family of proteoglycans, which function as collagen prolyl hydroxylases that are required for proper collagen biosynthesis, folding and assembly. This protein, like other family members, is thought to reside in the endoplasmic reticulum. Epigenetic inactivation of this gene is associated with breast and other cancers, suggesting that it may function as a tumor suppressor. [provided by RefSeq, Aug 2013]
UniProt Code:Q8IVL6
NCBI GenInfo Identifier:74714366
NCBI Gene ID:10536
NCBI Accession:Q8IVL6.1
UniProt Related Accession:Q8IVL6
Molecular Weight:82kDa
NCBI Full Name:Prolyl 3-hydroxylase 3
NCBI Synonym Full Names:prolyl 3-hydroxylase 3
NCBI Official Symbol:P3H3  
NCBI Official Synonym Symbols:GRCB; LEPREL2; HSU47926  
NCBI Protein Information:prolyl 3-hydroxylase 3
UniProt Protein Name:Prolyl 3-hydroxylase 3
UniProt Synonym Protein Names:Leprecan-like protein 2; Protein B
UniProt Gene Name:LEPREL2  
UniProt Entry Name:P3H3_HUMAN
Anti-LEPREL2 Antibody (CAB2293)Immunohistochemistry of paraffin-embedded rat lung using LEPREL2 antibody (CAB2293) at dilution of 1:200 (40x lens).
Anti-LEPREL2 Antibody (CAB2293)Immunohistochemistry of paraffin-embedded mouse heart using LEPREL2 antibody (CAB2293) at dilution of 1:200 (40x lens).
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