Anti-LEO1 Antibody (CAB8806)
- SKU:
- CAB8806
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- LEO1
- Synonyms:
- RDL
Description
| Product Name: | LEO1 Rabbit pAb |
| Product Code: | CAB8806 |
| Size: | 100uL |
| Synonyms: | LEO1, RDL |
| Applications: | WB, IHC, IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic Peptide of human LEO1 |
| Applications: | WB, IHC, IF |
| Recommended Dilutions: | WB 1:500 - 1:1000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HepG2, Jurkat, Mouse liver, Mouse brain, Rat brain |
| Immunogen: | A synthetic Peptide of human LEO1 |
| Purification Method: | Affinity purification |
| Storage: | Store at 4°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 123169 |
| Uniprot: | Q8WVC0 |
| Cellular Location: | Nucleus |
| Calculated MW: | 68kDa/75kDa |
| Observed MW: | 105KDa |
| UniProt Protein Function: | LEO1: a component of the PAF1 multifunctional complex involved in initiation and elongation, histone methylation and RNA processing. The PAF1 complex interacts with POLR2A. Overexpression of LEO1 induces cell growth arrest and premature senescence of fibroblasts. The PAF1 complex consists of at least of CDC73, PAF1, LEO1 and CTR9. Interacts with CDC73. Two isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription regulation Chromosomal Location of Human Ortholog: 15q21.2 Cellular Component: nucleoplasm; nucleolus Molecular Function:protein binding Biological Process: histone monoubiquitination; Wnt receptor signaling pathway; negative regulation of myeloid cell differentiation; endodermal cell fate commitment; transcription, DNA-dependent; positive regulation of RNA elongation from RNA polymerase II promoter; stem cell maintenance; histone H2B ubiquitination; positive regulation of mRNA 3'-end processing; mRNA polyadenylation; positive regulation of transcription from RNA polymerase II promoter |
| NCBI Summary: | LEO1, parafibromin (CDC73; MIM 607393), CTR9 (MIM 609366), and PAF1 (MIM 610506) form the PAF protein complex that associates with the RNA polymerase II subunit POLR2A (MIM 180660) and with a histone methyltransferase complex (Rozenblatt-Rosen et al., 2005 [PubMed 15632063]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q8WVC0 |
| NCBI GenInfo Identifier: | 20270337 |
| NCBI Gene ID: | 123169 |
| NCBI Accession: | NP_620147.1 |
| UniProt Related Accession: | Q8WVC0 |
| Molecular Weight: | 66kDa |
| NCBI Full Name: | RNA polymerase-associated protein LEO1 isoform 1 |
| NCBI Synonym Full Names: | LEO1 homolog, Paf1/RNA polymerase II complex component |
| NCBI Official Symbol: | LEO1 |
| NCBI Official Synonym Symbols: | RDL |
| NCBI Protein Information: | RNA polymerase-associated protein LEO1 |
| UniProt Protein Name: | RNA polymerase-associated protein LEO1 |
| UniProt Synonym Protein Names: | Replicative senescence down-regulated leo1-like protein |
| Protein Family: | RNA polymerase-associated protein |
| UniProt Gene Name: | LEO1 |
| UniProt Entry Name: | LEO1_HUMAN |
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