Cell Biology Antibodies 12
Anti-LEFTY2 Antibody (CAB9846)
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- SKU:
- CAB9846
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-LEFTY2 Antibody |
| Antibody SKU: | CAB9846 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 57-366 of human LEFTY2 (NP_003231.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HeLa, Mouse skin |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 57-366 of human LEFTY2 (NP_003231.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VRAQ YVVL LRRS HGDR SRGK RFSQ SFRE VAGR FLAS EAST HLLV FGME QRLP PNSE LVQA VLRL FQEP VPKA ALHR HGRL SPRS AQAR VTVE WLRV RDDG SNRT SLID SRLV SVHE SGWK AFDV TEAV NFWQ QLSR PRQP LLLQ VSVQ REHL GPLA SGAH KLVR FASQ GAPA GLGE PQLE LHTL DLRD YGAQ GDCD PEAP MTEG TRCC RQEM YIDL QGMK WAKN WVLE PPGF LAYE CVGT CQQP PEAL AFNW PFLG PRQC IASE TASL PMIV SIKE GGRT RPQV VSLP NMRV QKCS CASD GALV PRRL QP |
| Gene ID: | 7044 |
| Uniprot: | O00292 |
| Cellular Location: | Secreted |
| Calculated MW: | 37kDa/40kDa |
| Observed MW: | 41kDa |
| Synonyms: | LEFTY2, EBAF, LEFTA, LEFTYA, TGFB4 |
| Background: | This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene. Alternate splicing of this gene results in multiple transcript variants. |
| UniProt Protein Function: | LEFTY2: Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding. Defects in LEFTY2 are the cause of left-right axis malformations (LRAM). The defect includes left pulmonary isomerism, with cardiac anomalies characterized by complete atrioventricular canal defect and hypoplastic left ventricle, and interrupted inferior vena cava. Belongs to the TGF-beta family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Ligand, receptor tyrosine kinase; Cytokine; Secreted Chromosomal Location of Human Ortholog: 1q42.1 Cellular Component: extracellular matrix; extracellular space; extracellular region Molecular Function:growth factor activity; cytokine activity; transforming growth factor beta receptor binding Biological Process: regulation of apoptosis; platelet activation; platelet degranulation; regulation of MAPKKK cascade; multicellular organismal development; transforming growth factor beta receptor signaling pathway; cell growth; blood coagulation; cell development |
| NCBI Summary: | This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2010] |
| UniProt Code: | O00292 |
| NCBI GenInfo Identifier: | 27436881 |
| NCBI Gene ID: | 7044 |
| NCBI Accession: | NP_003231.2 |
| UniProt Secondary Accession: | O00292,O75611, Q5TE89, Q8NBQ9, B3KNH4, B4E332, E9PDM4 |
| UniProt Related Accession: | O00292 |
| Molecular Weight: | 37,093 Da |
| NCBI Full Name: | left-right determination factor 2 isoform 1 preproprotein |
| NCBI Synonym Full Names: | left-right determination factor 2 |
| NCBI Official Symbol: | LEFTY2 |
| NCBI Official Synonym Symbols: | EBAF; LEFTA; TGFB4; LEFTYA |
| NCBI Protein Information: | left-right determination factor 2; TGF-beta-4; protein lefty-2; protein lefty-A; left-right determination factor A; transforming growth factor beta-4; endometrial bleeding-associated factor |
| UniProt Protein Name: | Left-right determination factor 2 |
| UniProt Synonym Protein Names: | Endometrial bleeding-associated factor; Left-right determination factor A; Protein lefty-2; Protein lefty-A; Transforming growth factor beta-4; TGF-beta-4 |
| UniProt Gene Name: | LEFTY2 |
| UniProt Entry Name: | LFTY2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using LEFTY2 antibody (CAB9846) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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