Cell Biology Antibodies 16
Anti-LEFTY1 Antibody (CAB15389)
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- SKU:
- CAB15389
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Stem Cells
Description
| Antibody Name: | Anti-LEFTY1 Antibody |
| Antibody SKU: | CAB15389 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 77-366 of human LEFTY1 (NP_066277.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:200 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HT-29, SW480, BxPC-3, Mouse pancreas, Mouse spleen |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 77-366 of human LEFTY1 (NP_066277.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | RFSQ SFRE VAGR FLAL EAST HLLV FGME QRLP PNSE LVQA VLRL FQEP VPKA ALHR HGRL SPRS ARAR VTVE WLRV RDDG SNRT SLID SRLV SVHE SGWK AFDV TEAV NFWQ QLSR PRQP LLLQ VSVQ REHL GPLA SGAH KLVR FASQ GAPA GLGE PQLE LHTL DLGD YGAQ GDCD PEAP MTEG TRCC RQEM YIDL QGMK WAEN WVLE PPGF LAYE CVGT CRQP PEAL AFKW PFLG PRQC IASE TDSL PMIV SIKE GGRT RPQV VSLP NMRV QKCS CASD GALV PRRL QP |
| Gene ID: | 10637 |
| Uniprot: | O75610 |
| Cellular Location: | Secreted |
| Calculated MW: | 40kDa |
| Observed MW: | 39kDa |
| Synonyms: | LEFTY1, LEFTB, LEFTYB |
| Background: | This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in left-right asymmetry determination of organ systems during development. This gene is closely linked to both a related family member and a related pseudogene. |
| UniProt Protein Function: | LEFTY1: Required for left-right axis determination as a regulator of LEFTY2 and NODAL. Belongs to the TGF-beta family. |
| UniProt Protein Details: | Protein type:Cytokine; Ligand, receptor tyrosine kinase; Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 1q42.1 Cellular Component: extracellular space Molecular Function:cytokine activity; transforming growth factor beta receptor binding Biological Process: cell development; determination of left/right symmetry; heart morphogenesis; negative regulation of transcription from RNA polymerase II promoter; regulation of apoptosis; regulation of MAPKKK cascade; transforming growth factor beta receptor signaling pathway |
| NCBI Summary: | This gene encodes a member of the TGF-beta family of proteins. A similar secreted protein in mouse plays a role in left-right asymmetry determination of organ systems during development. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O75610 |
| NCBI GenInfo Identifier: | 13124321 |
| NCBI Gene ID: | 10637 |
| NCBI Accession: | O75610.1 |
| UniProt Secondary Accession: | O75610,Q53H67, Q5TE94, B2R7U0, |
| UniProt Related Accession: | O75610 |
| Molecular Weight: | 40,880 Da |
| NCBI Full Name: | Left-right determination factor 1 |
| NCBI Synonym Full Names: | left-right determination factor 1 |
| NCBI Official Symbol: | LEFTY1 |
| NCBI Official Synonym Symbols: | LEFTB; LEFTYB |
| NCBI Protein Information: | left-right determination factor 1 |
| UniProt Protein Name: | Left-right determination factor 1 |
| UniProt Synonym Protein Names: | Left-right determination factor B; Protein lefty-1; Protein lefty-B |
| Protein Family: | Left-right determination factor |
| UniProt Gene Name: | LEFTY1 |
| UniProt Entry Name: | LFTY1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using LEFTY1 antibody (CAB15389) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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