Cell Biology Antibodies 1

Anti-LDB2 Antibody (CAB10472)

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SKU:
CAB10472
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-LDB2 Antibody
Antibody SKU:CAB10472
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 204-373 of human LDB2 (NP_001281.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:U-87MG, Raji, Mouse kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 204-373 of human LDB2 (NP_001281.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LRLC VILE PMQE LMSR HKTY NLSP RDCL KTCL FQKW QRMV APPA EPTR QPTT KRRK RKNS TSST SNSS AGNN ANST GSKK KTTA ANLS LSSQ VPDV MVVG EPTL MGGE FGDE DERL ITRL ENTQ YDAA NGMD DEED FNNS PALG NNSP WNSK PPAT QETK SENP PPQA SQ
Gene ID:9079
Uniprot:O43679
Cellular Location:Nucleus
Calculated MW:38kDa/39kDa/42kDa
Observed MW:43kDa
Synonyms:LDB2, CLIM1, LDB-2, LDB1
Background:The protein encoded by this gene belongs to the LIM-domain binding family. Members of this family are characterized by a conserved nuclear localization sequence, an amino-terminal homodimerization domain and a carboxy-terminal LIM interaction domain. These proteins function as adapter molecules to allow assembly of transcriptional regulatory complexes. Genetic association studies suggest functions for this gene in rhegmatogenous retinal detachment and coronary artery disease. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:LDB2: Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. Belongs to the LDB family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Transcription, coactivator/corepressor; Cell development/differentiation

Chromosomal Location of Human Ortholog: 4p16

Cellular Component: leading edge; nucleus

Molecular Function:LIM domain binding; transcription cofactor activity

Biological Process: regulation of cell migration; regulation of kinase activity

NCBI Summary:The protein encoded by this gene belongs to the LIM-domain binding family. Members of this family are characterized by a conserved nuclear localization sequence, an amino-terminal homodimerization domain and a carboxy-terminal LIM interaction domain. These proteins function as adapter molecules to allow assembly of transcriptional regulatory complexes. Genetic association studies suggest functions for this gene in rhegmatogenous retinal detachment and coronary artery disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
UniProt Code:O43679
NCBI GenInfo Identifier:68565371
NCBI Gene ID:9079
NCBI Accession:O43679.1
UniProt Secondary Accession:O43679,O60619, O75480,
UniProt Related Accession:O43679
Molecular Weight:39,740 Da
NCBI Full Name:LIM domain-binding protein 2
NCBI Synonym Full Names:LIM domain binding 2
NCBI Official Symbol:LDB2  
NCBI Official Synonym Symbols:LDB1; CLIM1; LDB-2  
NCBI Protein Information:LIM domain-binding protein 2
UniProt Protein Name:LIM domain-binding protein 2
UniProt Synonym Protein Names:Carboxyl-terminal LIM domain-binding protein 1; CLIM-1; LIM domain-binding factor CLIM1
Protein Family:LIM domain-binding protein
UniProt Gene Name:LDB2  
UniProt Entry Name:LDB2_HUMAN
Anti-LDB2 Antibody (CAB10472)Western blot analysis of extracts of various cell lines, using LDB2 antibody (CAB10472) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.
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