Cell Biology Antibodies 14

Anti-LCMT2 Antibody (CAB17063)

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SKU:
CAB17063
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-LCMT2 Antibody
Antibody SKU:CAB17063
Antibody Size:20uL, 50 uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human LCMT2 (NP_055608.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human LCMT2 (NP_055608.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MGPR SRER RAGA VQNT NDSS ALSK RSLA ARGY VQDP FAAL LVPG AARR APLI HRGY YVRA RAVR HCVR AFLE QIGA PQAA LRAQ ILSL GAGF DSLY FRLK TAGR LARA AVWE VDFP DVAR RKAE RIGE TPEL CALT GPFE RGEP ASAL CFES ADYC ILGL DLRQ LQRV EEAL GAAG LDAA SPTL LLAE AVLT YLEP ESAA ALIA WAAQ RFPN ALFV VYEQ MRPQ DAFG QFML QHFR QLNS PLHG LERF PDVE AQRR RFLQ AGWT ACGA VDMN EFYH CFLP AEER RRVE NIEP FDEF EEWH
Gene ID:9836
Uniprot:O60294
Cellular Location:
Calculated MW:
Observed MW:Refer to figures
Synonyms:LCMT2, PPM2, TYW4
Background:The protein encoded by this intronless gene belongs to the highly variable methyltransferase superfamily. This gene is the inferred homolog of the Saccharomyces cerevisiae carboxymethyltransferase gene PPM2 that is essential for the synthesis of the hypermodified guanosine Wybutosine (yW).
UniProt Protein Function:LCMT2: Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. May methylate the carboxyl group of leucine residues to form alpha- leucine ester residues. Belongs to the methyltransferase superfamily. LCMT family.
UniProt Protein Details:

Protein type:Lipid Metabolism - androgen and estrogen; Other Amino Acids Metabolism - selenoamino acid; Amino Acid Metabolism - tyrosine; Methyltransferase; Amino Acid Metabolism - histidine; EC 2.1.1.290; EC 2.3.1.231

Chromosomal Location of Human Ortholog: 15q15.3

Cellular Component: cytoplasm; cytosol

Molecular Function:protein binding; S-adenosylmethionine-dependent methyltransferase activity; tRNA methyltransferase activity

Biological Process: tRNA methylation; tRNA modification; wybutosine biosynthetic process

NCBI Summary:The protein encoded by this intronless gene belongs to the highly variable methyltransferase superfamily. This gene is the inferred homolog of the Saccharomyces cerevisiae carboxymethyltransferase gene PPM2 that is essential for the synthesis of the hypermodified guanosine Wybutosine (yW). [provided by RefSeq, Jul 2008]
UniProt Code:O60294
NCBI GenInfo Identifier:47605773
NCBI Gene ID:9836
NCBI Accession:O60294.3
UniProt Secondary Accession:O60294,Q4JFT6, Q96B55, Q9NR10,
UniProt Related Accession:O60294
Molecular Weight:75,602 Da
NCBI Full Name:tRNA wybutosine-synthesizing protein 4
NCBI Synonym Full Names:leucine carboxyl methyltransferase 2
NCBI Official Symbol:LCMT2  
NCBI Official Synonym Symbols:PPM2; TYW4  
NCBI Protein Information:tRNA wybutosine-synthesizing protein 4
UniProt Protein Name:tRNA wybutosine-synthesizing protein 4
UniProt Synonym Protein Names:Leucine carboxyl methyltransferase 2; tRNA(Phe) (7-(3-amino-3-(methoxycarbonyl)propyl)wyosine(37)-N)-methoxycarbonyltransferase; tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase
Protein Family:tRNA wybutosine-synthesizing protein
UniProt Gene Name:LCMT2  
UniProt Entry Name:TYW4_HUMAN
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