Immunology Antibodies 1

Anti-LAX1 Antibody (CAB12218)

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SKU:
CAB12218
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology

Description

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Antibody Name:Anti-LAX1 Antibody
Antibody SKU:CAB12218
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 77-398 of human LAX1 (NP_060243.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:Raji, Mouse liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 77-398 of human LAX1 (NP_060243.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MPLL TLPQ TRQR AKNI YDIL PWRQ EDLG RHES RSMR IFST ESLL SRNS ESPE HVPS QAGN AFQE HTAH IHAT EYAV GIYD NAMV PQMC GNLT PSAH CINV RASR DCAS ISSE DSHD YVNV PTAE EIAE TLAS TKSP SRNL FVLP STQK LEFT EERD EGCG DAGD CTSL YSPG AEDS DSLS NGEG SSQI SNDY VNMT GLDL SAIQ ERQL WVAF QCCR DYEN VPAA DPSG SQQQ AEKD VPSS NIGH VEDK TDDP GTHV QCVK RTFL ASGD YADF QPFT QSED SQMK HREE MSNE DSSD YENV LTAK LGGR DSEQ GPGT QLLP DE
Gene ID:54900
Uniprot:Q8IWV1
Cellular Location:Cell membrane, Single-pass type III membrane protein
Calculated MW:35kDa/42kDa/44kDa
Observed MW:44kDa
Synonyms:LAX1, LAX
Background:
UniProt Protein Function:LAX1: Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and BCR (B-cell antigen receptor)- mediated signaling in B-cells. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Adaptor/scaffold; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: cytosol; Golgi apparatus; integral to membrane; lipid raft; membrane; plasma membrane

Molecular Function:protein binding; protein kinase binding; SH2 domain binding

Biological Process: B cell activation; immune response; inactivation of MAPK activity; negative regulation of T cell activation

UniProt Code:Q8IWV1
NCBI GenInfo Identifier:74728197
NCBI Gene ID:54900
NCBI Accession:Q8IWV1.1
UniProt Secondary Accession:Q8IWV1,Q6NSZ6, Q9NXB4, B7Z744, J3KP69,
UniProt Related Accession:Q8IWV1
Molecular Weight:44kDa
NCBI Full Name:Lymphocyte transmembrane adapter 1
NCBI Synonym Full Names:lymphocyte transmembrane adaptor 1
NCBI Official Symbol:LAX1  
NCBI Official Synonym Symbols:LAX  
NCBI Protein Information:lymphocyte transmembrane adapter 1
UniProt Protein Name:Lymphocyte transmembrane adapter 1
UniProt Synonym Protein Names:Linker for activation of X cells; Membrane-associated adapter protein LAX
Protein Family:Lymphocyte transmembrane adapter
UniProt Gene Name:LAX1  
Anti-LAX1 Antibody (CAB12218)Western blot analysis of extracts of various cell lines, using LAX1 antibody (CAB12218) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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