Immunology Antibodies 1
Anti-LAX1 Antibody (CAB12218)
- SKU:
- CAB12218
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
Antibody Name: | Anti-LAX1 Antibody |
Antibody SKU: | CAB12218 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB |
Reactivity: | Human, Mouse |
Host Species: | Rabbit |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 77-398 of human LAX1 (NP_060243.2). |
Application: | WB |
Recommended Dilution: | WB 1:500 - 1:2000 |
Reactivity: | Human, Mouse |
Positive Samples: | Raji, Mouse liver |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 77-398 of human LAX1 (NP_060243.2). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | MPLL TLPQ TRQR AKNI YDIL PWRQ EDLG RHES RSMR IFST ESLL SRNS ESPE HVPS QAGN AFQE HTAH IHAT EYAV GIYD NAMV PQMC GNLT PSAH CINV RASR DCAS ISSE DSHD YVNV PTAE EIAE TLAS TKSP SRNL FVLP STQK LEFT EERD EGCG DAGD CTSL YSPG AEDS DSLS NGEG SSQI SNDY VNMT GLDL SAIQ ERQL WVAF QCCR DYEN VPAA DPSG SQQQ AEKD VPSS NIGH VEDK TDDP GTHV QCVK RTFL ASGD YADF QPFT QSED SQMK HREE MSNE DSSD YENV LTAK LGGR DSEQ GPGT QLLP DE |
Gene ID: | 54900 |
Uniprot: | Q8IWV1 |
Cellular Location: | Cell membrane, Single-pass type III membrane protein |
Calculated MW: | 35kDa/42kDa/44kDa |
Observed MW: | 44kDa |
Synonyms: | LAX1, LAX |
Background: |
UniProt Protein Function: | LAX1: Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and BCR (B-cell antigen receptor)- mediated signaling in B-cells. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Adaptor/scaffold; Membrane protein, integral Chromosomal Location of Human Ortholog: 1q32.1 Cellular Component: cytosol; Golgi apparatus; integral to membrane; lipid raft; membrane; plasma membrane Molecular Function:protein binding; protein kinase binding; SH2 domain binding Biological Process: B cell activation; immune response; inactivation of MAPK activity; negative regulation of T cell activation |
UniProt Code: | Q8IWV1 |
NCBI GenInfo Identifier: | 74728197 |
NCBI Gene ID: | 54900 |
NCBI Accession: | Q8IWV1.1 |
UniProt Secondary Accession: | Q8IWV1,Q6NSZ6, Q9NXB4, B7Z744, J3KP69, |
UniProt Related Accession: | Q8IWV1 |
Molecular Weight: | 44kDa |
NCBI Full Name: | Lymphocyte transmembrane adapter 1 |
NCBI Synonym Full Names: | lymphocyte transmembrane adaptor 1 |
NCBI Official Symbol: | LAX1 |
NCBI Official Synonym Symbols: | LAX |
NCBI Protein Information: | lymphocyte transmembrane adapter 1 |
UniProt Protein Name: | Lymphocyte transmembrane adapter 1 |
UniProt Synonym Protein Names: | Linker for activation of X cells; Membrane-associated adapter protein LAX |
Protein Family: | Lymphocyte transmembrane adapter |
UniProt Gene Name: | LAX1 |