Cell Cycle Antibodies 1
Anti-LATS2 Antibody (CAB16249)
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- SKU:
- CAB16249
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Description
| Antibody Name: | Anti-LATS2 Antibody |
| Antibody SKU: | CAB16249 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human LATS2 (NP_055387.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse brain |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human LATS2 (NP_055387.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MRPK TFPA TTYS GNSR QRLQ EIRE GLKQ PSKS SVQG LPAG PNSD TSLD AKVL GSKD ATRQ QQQM RATP KFGP YQKA LREI RYSL LPFA NESG TSAA AEVN |
| Gene ID: | 26524 |
| Uniprot: | Q9NRM7 |
| Cellular Location: | Cytoplasm, Nucleus, centrosome, cytoskeleton, microtubule organizing center, spindle pole |
| Calculated MW: | 120kDa |
| Observed MW: | 150kDa |
| Synonyms: | LATS2, KPM |
| Background: | This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. |
| UniProt Protein Function: | LATS2: an AGC kinase of the NDR family of kinases. A tumor suppressor of the LATS family. Plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Inhibits cell growth at the G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor. Interacts with and is phosphorylated by STK6. Ectopic expression induces apoptosis in lung cancer cell lines. Negatively regulates androgen receptor, and is downregulated in prostate cancer |
| UniProt Protein Details: | Protein type:Nuclear receptor co-regulator; Kinase, protein; Tumor suppressor; Protein kinase, AGC; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); AGC group; NDR family Chromosomal Location of Human Ortholog: 13q12.11 Cellular Component: cytoplasm; cytosol; microtubule organizing center; nucleus; spindle pole Molecular Function:ATP binding; protein binding; protein serine/threonine kinase activity Biological Process: G1/S transition of mitotic cell cycle; hormone-mediated signaling; negative regulation of cyclin-dependent protein kinase activity; peptidyl-serine phosphorylation; positive regulation of apoptosis; protein amino acid phosphorylation; regulation of organ growth |
| NCBI Summary: | This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9NRM7 |
| NCBI GenInfo Identifier: | 212276441 |
| NCBI Gene ID: | 26524 |
| NCBI Accession: | Q9NRM7.2 |
| UniProt Secondary Accession: | Q9NRM7,Q9P2X1, B1AM47, |
| UniProt Related Accession: | Q9NRM7 |
| Molecular Weight: | 120,136 Da |
| NCBI Full Name: | Serine/threonine-protein kinase LATS2 |
| NCBI Synonym Full Names: | large tumor suppressor kinase 2 |
| NCBI Official Symbol: | LATS2 |
| NCBI Official Synonym Symbols: | KPM |
| NCBI Protein Information: | serine/threonine-protein kinase LATS2 |
| UniProt Protein Name: | Serine/threonine-protein kinase LATS2 |
| UniProt Synonym Protein Names: | Kinase phosphorylated during mitosis protein; Large tumor suppressor homolog 2; Serine/threonine-protein kinase kpm; Warts-like kinase |
| Protein Family: | Serine/threonine-protein kinase |
| UniProt Gene Name: | LATS2 |
| UniProt Entry Name: | LATS2_HUMAN |
 | Western blot analysis of extracts of Mouse brain, using LATS2 antibody (CAB16249) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded Mouse heart using LATS2 Rabbit pAb (CAB16249) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded Rat heart using LATS2 Rabbit pAb (CAB16249) at dilution of 1:100 (40x lens). |
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