Description
| Antibody Name: | Anti-LAMP2 Antibody |
| Antibody SKU: | CAB1961 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-300 of human LAMP2 (NP_054701.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human |
| Positive Samples: | MCF7, U-937 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-300 of human LAMP2 (NP_054701.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ELNL TDSE NATC LYAK WQMN FTVR YETT NKTY KTVT ISDH GTVT YNGS ICGD DQNG PKIA VQFG PGFS WIAN FTKA ASTY SIDS VSFS YNTG DNTT FPDA EDKG ILTV DELL AIRI PLND LFRC NSLS TLEK NDVV QHYW DVLV QAFV QNGT VSTN EFLC DKDK TSTV APTI HTTV PSPT TTPT PKEK PEAG TYSV NNGN DTCL LATM GLQL NITQ DKVA SVIN INPN TTHS TGSC RSHT ALLR LNSS TIKY LDFV FAVK NENR FYLK EVN |
| Gene ID: | 3920 |
| Uniprot: | P13473 |
| Cellular Location: | Cell membrane, Endosome membrane, Lysosome membrane, Single-pass type I membrane protein |
| Calculated MW: | 44kDa/45kDa |
| Observed MW: | 118kDa |
| Synonyms: | LAMP2, CD107b, LAMP-2, LAMPB, LGP-96, LGP110 |
| Background: | The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome. Alternative splicing of this gene results in multiple transcript variants encoding distinct proteins. |
| UniProt Protein Function: | LAMP2: Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens. Defects in LAMP2 are the cause of Danon disease (DAND); also known as glycogen storage disease type 2B (GSD2B). DAND is a lysosomal glycogen storage disease characterized by the clinical triad of cardiomyopathy, vacuolar myopathy and mental retardation. It is often associated with an accumulation of glycogen in muscle and lysosomes. Belongs to the LAMP family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: Xq24 Cellular Component: phagocytic vesicle membrane; membrane; lysosome; lysosomal membrane; late endosome membrane; late endosome; plasma membrane; integral to membrane; platelet dense granule membrane Molecular Function:protein domain specific binding; enzyme binding Biological Process: platelet activation; platelet degranulation; protein stabilization; blood coagulation Disease: Danon Disease |
| NCBI Summary: | The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome. Alternative splicing of this gene results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P13473 |
| NCBI GenInfo Identifier: | 1708854 |
| NCBI Gene ID: | 3920 |
| NCBI Accession: | P13473.2 |
| UniProt Secondary Accession: | P13473,Q16641, Q6Q3G8, Q96J30, Q99534, Q9UD93, A8K4X5 D3DTF0, |
| UniProt Related Accession: | P13473 |
| Molecular Weight: | 410 |
| NCBI Full Name: | Lysosome-associated membrane glycoprotein 2 |
| NCBI Synonym Full Names: | lysosomal-associated membrane protein 2 |
| NCBI Official Symbol: | LAMP2 |
| NCBI Official Synonym Symbols: | LAMPB; CD107b; LAMP-2; LGP110 |
| NCBI Protein Information: | lysosome-associated membrane glycoprotein 2; CD107 antigen-like family member B |
| UniProt Protein Name: | Lysosome-associated membrane glycoprotein 2 |
| UniProt Synonym Protein Names: | CD107 antigen-like family member B; CD_antigen: CD107b |
| Protein Family: | Lysosome-associated membrane glycoprotein |
| UniProt Gene Name: | LAMP2 |
| UniProt Entry Name: | LAMP2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using LAMP2 antibody (CAB1961) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded human breast cancer using LAMP2 Antibody (CAB1961) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human gastric cancer using LAMP2 Antibody (CAB1961) at dilution of 1:100 (40x lens). |
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Additional Information
Product Type: |
Antibody |
Reactivity: |
Human |
Host Species: |
Rabbit |
Isotype: |
IgG |
Research Area: |
Autophagy |
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