Cell Biology Antibodies 17
Anti-Lamin B2 Antibody (CAB5001)
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- SKU:
- CAB5001
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- EPM9
- Synonyms:
- LAMB2
- Synonyms:
- LMN2
Description
| Product Name: | Lamin B2 Rabbit mAb |
| Product Code: | CAB5001 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | EPM9, LAMB2, LMN2 |
| Applications: | WB, IHC, IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human Lamin B2 |
| Applications: | WB, IHC, IF |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, RD, Jurkat |
| Immunogen: | A synthesized peptide derived from human Lamin B2 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 84823 |
| Uniprot: | Q03252 |
| Cellular Location: | Lipid-anchor, Nucleoplasmic side, Nucleus inner membrane |
| Calculated MW: | 68kDa |
| Observed MW: | 68KDa |
| UniProt Protein Function: | Lamin B2: nuclear lamins are intermediate filament proteins that constitute the lattice-like matrix at the inner face of the nuclear membrane that underlies the nuclear envelop. The lamins, highly conserved throughout evolution, are encoded by three genes in the human: LMNA, LMNB1, and LMNB2. The A-type lamins (lamin A/C) are developmentally regulated and are generally expressed in differentiated cells. The anchoring of chromatin to the nuclear lamina is involved in the control of gene expression and in DNA replication and repair. During mitosis, the nuclear lamina is reversibly disassembled as the lamin proteins are phosphorylated. B-type lamins are phosphorylated within minutes of engaging the IgM surface receptor of resting splenic B cells. Lamin B2 may be lost during the follicle centre stage of B-cell differentiation in humans. Nuclear lamins are cleaved by caspases during apoptosis. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Cytoskeletal Chromosomal Location of Human Ortholog: 19p13.3 Cellular Component: lamin filament; nuclear inner membrane Molecular Function:structural molecule activity Disease: Lipodystrophy, Partial, Acquired, Susceptibility To |
| UniProt Code: | Q03252 |
| NCBI GenInfo Identifier: | 23503078 |
| NCBI Gene ID: | |
| NCBI Accession: | Q03252.3 |
| Molecular Weight: | |
| NCBI Full Name: | Lamin-B2 |
| UniProt Protein Name: | Lamin-B2 |
| Protein Family: | Lamin |
| UniProt Gene Name: | LMNB2 |
| UniProt Entry Name: | LMNB2_HUMAN |
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