Cell Biology Antibodies 16
Anti-Lamin B1 Antibody (CAB11495)
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- SKU:
- CAB11495
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-Lamin B1 Antibody |
| Antibody SKU: | CAB11495 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human Lamin B1 |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, HeLa+Staurosporine, Jurkat, U-87MG, Mouse liver, Mouse brain, Mouse spleen, Rat liver, Rat testis |
| Immunogen: | A synthesized peptide derived from human Lamin B1 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 4001 |
| Uniprot: | P20700 |
| Cellular Location: | Lipid-anchor, Nucleoplasmic side, Nucleus inner membrane |
| Calculated MW: | 70kDa |
| Observed MW: | 45KDa/70KDa |
 | Western blot - Lamin B1 Rabbit mAb (CAB11495) |
| Synonyms: | ADLD, LMN, LMN2, LMNB |
| Background: | This gene encodes one of the two B-type lamin proteins and is a component of the nuclear lamina. A duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015] |
| UniProt Protein Function: | Lamin B1: nuclear lamins are intermediate filament proteins that constitute the lattice-like matrix at the inner face of the nuclear membrane that underlies the nuclear envelop. The lamins, highly conserved throughout evolution, are encoded by three genes in the human: LMNA, LMNB1, and LMNB2. The A-type lamins (lamin A/C) are developmentally regulated and are generally expressed in differentiated cells. The anchoring of chromatin to the nuclear lamina is involved in the control of gene expression and in DNA replication and repair. During mitosis, the nuclear lamina is reversibly disassembled as the lamin proteins are phosphorylated. B-type lamins are phosphorylated within minutes of engaging the IgM surface receptor of resting splenic B cells. Nuclear lamins are cleaved by caspases during apoptosis. |
| UniProt Protein Details: | Protein type:Cytoskeletal Chromosomal Location of Human Ortholog: 5q23.2 Cellular Component: nucleoplasm; nuclear membrane; membrane; lamin filament; nuclear inner membrane; nuclear envelope Molecular Function:phospholipase binding; structural molecule activity Biological Process: apoptosis; cell structure disassembly during apoptosis Disease: Leukodystrophy, Demyelinating, Adult-onset, Autosomal Dominant |
| NCBI Summary: | This gene encodes one of the two B-type lamin proteins and is a component of the nuclear lamina. A duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015] |
| UniProt Code: | P20700 |
| NCBI GenInfo Identifier: | 125953 |
| NCBI Gene ID: | 4001 |
| NCBI Accession: | P20700.2 |
| UniProt Related Accession: | P20700 |
| Molecular Weight: | ~ 68kDa |
| NCBI Full Name: | Lamin-B1 |
| NCBI Synonym Full Names: | lamin B1 |
| NCBI Official Symbol: | LMNB1 |
| NCBI Official Synonym Symbols: | LMN; ADLD; LMN2; LMNB |
| NCBI Protein Information: | lamin-B1 |
| UniProt Protein Name: | Lamin-B1 |
| Protein Family: | Light-harvesting protein |
| UniProt Gene Name: | LMNB1 |
| UniProt Entry Name: | LMNB1_HUMAN |
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