Anti-Lambda Light chain Antibody (CAB19831)
- SKU:
- CAB19831
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- IGLV151
- Synonyms:
- V1-19
Description
| Product Name: | Lambda Light chain Rabbit mAb |
| Product Code: | CAB19831 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | IGLV151, V1-19 |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human Lambda Light chain |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse spleen, Rat spleen |
| Immunogen: | A synthesized peptide derived from human Lambda Light chain |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 28820 |
| Uniprot: | P01701/P01842 |
| Calculated MW: | 25kDa |
| Observed MW: | 25KDa |
| UniProt Protein Function: | IGLV1-51: V segment of the variable region of immunoglobulins light chain that participates to the antigen recognition. Immunoglobulins (Igs), also known as antibodies, are membrane- bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound Igs serve as receptors which, upon binding of a specific antigen (Ag), trigger the clonal expansion and differentiation of B lymphocytes into Ig-secreting plasma cells. Secreted Igs mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable region of one heavy chain, together with that of its associated light chain. Thus, each Ig has two antigen binding sites with remarkable affinity for a particular antigen. The variable regions are assembled by a process called V(D)J recombination and can then be subjected to somatic hypermutation after exposure to antigen to allow affinity maturation for a particular Ag (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Immunoglobulins are composed of two identical heavy chains and two identical light chains, linked by disulfide bonds. {ECO:0000303|PubMed:20176268} |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | P01701 |
| NCBI GenInfo Identifier: | 126541 |
| NCBI Gene ID: | 3535 |
| NCBI Accession: | P01701.1 |
| UniProt Secondary Accession: | P01701,P0CG04 |
| UniProt Related Accession: | P01701 |
| Molecular Weight: | ~22.5kDa |
| NCBI Full Name: | Ig lambda chain V-I region NEW |
| NCBI Synonym Full Names: | |
| NCBI Official Symbol: | |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | |
| UniProt Protein Name: | Ig lambda chain V-I region NEW |
| UniProt Synonym Protein Names: | |
| Protein Family: | |
| UniProt Gene Name: | |
| UniProt Entry Name: | LV103_HUMAN |
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